"CD80" Related Products


Recombinant Cynomolgus Monkey CD80 protein, His-tagged

Cat.No.: CD80-274C
Product Overview: Recombinant Cynomolgus Monkey CD80(Val35-Asn242) fused with His tag at C-terminal was expressed in HEK293.
Description: B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20 - 100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. Mature cynomolgus B7-1 consists of a 208 aa extracellular domain (ECD) with two immunoglobulin-like domains, a 21 aa transmembrane domain, and a 25 aa cytoplasmic domain. Within the ECD, cynomolgus B7-1 shares 97%, 51%, and 54% aa sequence identity with human, mouse, and rat B7-1, respectively. Both human and mouse B7-1 and B7-2 can bind to either human or mouse CD28 and CTLA-4. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells.
Source: HEK293
Species: Cynomolgus Monkey
Tag : His
Predicted N Terminal: Val35
Form: Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity: Measured by its binding ability in a functional ELISA. When Recombinant Cynomolgus Monkey B7-1/CD80 is immobilized at 0.5 µg/mL (100 µL/well), the concentration of Recombinant Human CTLA-4 Fc Chimera that produces 50% of the optimal binding response is approximately 5-30 ng/mL.
Molecular Mass: Predicted Molecular Mass: 25 kDa
SDS-PAGE: 35-45 kDa, reducing conditions
Endotoxin: <0.1 EU per 1 μg of the protein by the LAL method.
Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution: Reconstitute at 1 mg/mL in PBS.
Gene Name: CD80 CD80 molecule [ Macaca fascicularis ]
Official Symbol: CD80
Synonyms: CD80; CD80 molecule
Gene ID: 102140078
UniProt ID: Q8BKG4

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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