Recombinant Cynomolgus PDCD1 protein, His-tagged

Cat.No. : PDCD1-5223C
Product Overview : Recombinant Cynomolgus PDCD1 protein (Leu25-Gln167), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293).
Availability December 09, 2024
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Description : Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
Source : HEK293
Species : Cynomolgus
Tag : His
Form : Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 16.8 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Protein length : 143
Endotoxin : Less than 1.0 EU per ug by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Publication :
An anti-PD-1–GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy (2022)
Gene Name : PDCD1
Official Symbol : PDCD1
Synonyms : CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
Gene ID : 102123659
mRNA Refseq : NM_001284136.1
Protein Refseq : NP_001271065.1
UniProt ID : B0LAJ3

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
06/06/2021

    Timely antibody validation, a valuable asset for our laboratory.

    02/12/2021

      Precise protein quantification, fundamental for maintaining data accuracy.

      06/20/2019

        Dependable peptide synthesis, accelerates our peptide-based projects effectively.

        Q&As (14)

        Ask a question
        What are the mechanisms by which PDCD1 modulates the immune response to viral infections? 07/31/2022

        PDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.

        What are the mechanisms by which PDCD1 modulates the immune response to viral infections? 11/09/2021

        PDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.

        What role does PDCD1 play in the development of immune tolerance? 10/15/2021

        PDCD1 helps develop immune tolerance, preventing overactive immune responses.

        How does PDCD1 influence the balance between immune activation and autoimmunity? 05/23/2021

        PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.

        How does PDCD1 contribute to the exhaustion of T cells in chronic infections and cancer? 08/13/2020

        PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.

        How does PDCD1 influence the balance between immune activation and autoimmunity? 08/05/2020

        PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.

        What is the impact of PDCD1 on the effectiveness of immunotherapy in treating cancers? 12/05/2019

        PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.

        How does PDCD1 contribute to the exhaustion of T cells in chronic infections and cancer? 11/21/2019

        PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.

        How does PDCD1 (PD-1) regulate immune checkpoint pathways in T cells? 04/24/2019

        PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.

        What is the impact of PDCD1 on the effectiveness of immunotherapy in treating cancers? 01/19/2019

        PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.

        What role does PDCD1 play in the development of immune tolerance? 12/08/2018

        PDCD1 helps develop immune tolerance, preventing overactive immune responses.

        How do alterations in PDCD1 expression or signaling affect autoimmune disease progression? 06/24/2018

        Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.

        How does PDCD1 (PD-1) regulate immune checkpoint pathways in T cells? 06/24/2018

        PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.

        How do alterations in PDCD1 expression or signaling affect autoimmune disease progression? 02/06/2018

        Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.

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