Recombinant Cynomolgus/Rhesus macaque IL4R protein, Fc-tagged
| Cat.No. : | IL4R-19C |
| Product Overview : | Recombinant Cynomolgus/Rhesus macaque IL4R protein (Met26-Arg232), fused to human IgG1 Fc tag at C-terminus, was expressed in human 293 cells (HEK293).In the region Met26-Arg232, the AA sequence of Cynomolgus and Rhesus macaque IL4R are homologus. |
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| Description : | IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124) subunit and the 70 kDa common cytokine γc chain (CD132). Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL13Ra1 to form the type II receptor which is responsive to both IL4 and IL13. Interleukin-4 receptor has been shown to interact with SHC1. |
| Source : | HEK293 |
| Species : | Cynomolgus/Rhesus macaque |
| Tag : | human IgG1 Fc |
| Form : | Lyophilized from 0.22 um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
| Molecular Mass : | The protein has a calculated MW of 50.4 kDa. The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Protein length : | 207 |
| Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
| Purity : | >95% as determined by SDS-PAGE. |
| Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
| Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
| Gene Name : | IL4R |
| Official Symbol : | IL4R |
| Synonyms : | IL4R; interleukin 4 receptor; interleukin-4 receptor subunit alpha; CD124; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain; IL4RA; IL-4RA |
| Gene ID : | 102133649 |
| mRNA Refseq : | XM_005591515.2 |
| Protein Refseq : | XP_005591572.1 |
| UniProt ID : | G7Q0S7 |
Products Types
| ◆ Recombinant Protein | ||
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| IL4R-2437P | Recombinant Pig IL4R Protein (33-240 aa), His-sumostar-tagged | +Inquiry |
| IL4R-2388P | Recombinant Pig IL4R Protein (33-240 aa), His-tagged | +Inquiry |
| IL4R-5179H | Recombinant Human IL4R Protein, GST-tagged | +Inquiry |
| ◆ Lysates | ||
| IL4R-2719HCL | Recombinant Human IL4R cell lysate | +Inquiry |
| IL4R-1051RCL | Recombinant Rat IL4R cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIL4R is a synthetic protein that mimics the IL-4 signaling pathway in nature and binds to the IL-4 receptor in cells, which can be used to study the IL-4 signaling pathway and related diseases.
Common IL4R production technologies include prokaryotic expression systems and mammalian cell expression systems.
This protein is used in tumor immunotherapy, which can promote anti-tumor immune response and enhance the anti-tumor effect of cytotoxic T lymphocytes.
It is mainly used in immunology, drug research and other fields. It is also widely used in vaccines, biotechnology, cancer treatment and so on.
IL4R is used to treat severe pheochromocytome-induced aerodoritis and was approved by the FDA as the first drug to treat this disease.
IL4R cannot generally be administered orally, and needs to be administered by injection or intravenous drip.
Customer Reviews (3)
Write a reviewEasy to attach to the surface of cells or materials. -
It has growth factor activity to promote cell growth and proliferation. -
In animals or humans caused by the prone production of antibodies. -
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