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Recombinant Human IL4R Protein

Cat.No. : IL4R-5180H
Product Overview : Human IL4R full-length ORF (NP_001008699.1) recombinant protein without tag.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq
Source : Wheat Germ
Species : Human
Form : Liquid
Molecular Mass : 25.6 kDa
AA Sequence : MGWLCSGLLFPVSCLVLLQVASSGN MKVLQEPTCVSDYMSISTCEWKMNG PTNCSTELRLLYQLVFLLSEAHTCI PENNGGAGCVCHLLMDDVVSADNYT LDLWAGQQLLWKGSFKPSEHVKPRA PGNLTVHTNVSDTLLLTWSNPYPPD NYLYNHLTYAVNIWSENDPADFRIY NVTYLEPSLRIAASTLKSGISYRAR VRAWAQCYNTTWSEWSPSTKWHNSN IC
Applications : Antibody Production
Functional Study
Compound Screening
Usage : Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 25 mM Tris-HCl of pH8.0 containing 2% glycerol.
Gene Name : IL4R interleukin 4 receptor [ Homo sapiens ]
Official Symbol : IL4R
Synonyms : IL4R; interleukin 4 receptor; interleukin-4 receptor subunit alpha; CD124; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain; IL4RA; IL-4RA;
Gene ID : 3566
mRNA Refseq : NM_000418
Protein Refseq : NP_000409
MIM : 147781
UniProt ID : P24394

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How about function of IL4R? 10/15/2022

IL4R is a synthetic protein that mimics the IL-4 signaling pathway in nature and binds to the IL-4 receptor in cells, which can be used to study the IL-4 signaling pathway and related diseases.

What is the production technology of IL4R? 02/23/2022

Common IL4R production technologies include prokaryotic expression systems and mammalian cell expression systems.

Which application of IL4R in tumor therapy? 01/26/2022

This protein is used in tumor immunotherapy, which can promote anti-tumor immune response and enhance the anti-tumor effect of cytotoxic T lymphocytes.

In what fields does IL4R have applications? 07/09/2021

It is mainly used in immunology, drug research and other fields. It is also widely used in vaccines, biotechnology, cancer treatment and so on.

Are there have application of IL4R in the treatment of asthma? 03/23/2021

IL4R is used to treat severe pheochromocytome-induced aerodoritis and was approved by the FDA as the first drug to treat this disease.

Can IL4R be administered orally? 05/08/2020

IL4R cannot generally be administered orally, and needs to be administered by injection or intravenous drip.

Customer Reviews (3)

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Reviews
06/30/2022

    Easy to attach to the surface of cells or materials.

    09/29/2021

      It has growth factor activity to promote cell growth and proliferation.

      02/27/2019

        In animals or humans caused by the prone production of antibodies.

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