Cat. No. : |
IL1B-259F |
Description : |
IL-1 beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine. |
Source : |
Yeast. |
Formulation/ Reconstitution : |
Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein. |
Purification : |
Ion-exchange chromatography. |
Purity : |
>95% as visualized by SDS-PAGE analysis. |
Amino Acid Sequence : |
AAIQSQDYTF RDISQKSLVL SGSYELRALH LNGQNMNQQV VFRMSFVHGE ENSKKIPVVL CIKKNNLYLS CVMKDGKPTL QLEMLDPKVY PKKKMEKRFV FNKTEIKGNV EFESSQFPNW YISTSQAEEM PVFLGNTKGG QDITDFIMES AS. |
Bioactivity : |
In testing. |
Stability And Storage : |
Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles. |