Recombinant Mouse Interleukin 1 Beta, His-tagged

• Cat.No.: Il1b-105M
• Product Overview: Recombinant mouse IL-1β, fused to His tag, was expressed in E.coli and purified by using conventional chromatography techniques,21kDa (189aa).

Specification

• Species: Mouse
• Source: E.coli
• Tag: His
• Description: IL-1β is an inflammatory cytokine that might modulate angiogenesis by directly interacting with vascular endothelial cells or enhancing the production of proangiogenic factors via paracrine control. IL-1β stimulates endothelial cell migration and proliferation, adhesion-molecule expression, inflammatory mediator production, and leukocyte recruitment. IL-1β is required for tumor growth, metastasis, and angiogenesis in several animal models.
• Sequences of amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMVPI RQLHYRLRDE QQKSLVLSDP YELKALHLNG QNINQQVIFS MSFVQGEPSN DKIPVALGLK GKNLYLSCVM KDGTPTLQLE SVDPKQYPKK KMEKRFVFNK IEVKSKVEFE SAEFPNWYIS TSQAEHKPVF LGNNSGQDII DFTMESVSS
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
• Purity: > 90% by SDS - PAGE
• Concentration: 1 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: Il1b interleukin 1 beta [ Mus musculus ]
• Synonyms: Catabolin; IL-1; IL-1B; IL1-BETA; IL1F2; pro-interleukin-1-beta; IL-1 beta; interleukin 1, beta; preinterleukin 1 beta; Il1b; interleukin 1 beta; IL-1beta; OTTMUSP00000016525
• Gene ID: 16176
• mRNA Refseq: NM_008361
• Protein Refseq: NP_032387
• UniProt ID: P10749
• Chromosome Location: 2 F; 2 73.0 cM
• Pathway: Apoptosis; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; MAPK signaling pathway; Toll-like receptor signaling pathway; Type I diabetes mellitus
• Function: cytokine activity; growth factor activity; interleukin-1 receptor binding