Recombinant Full Length Human ADSS1 Protein, C-Flag-tagged
Cat.No. : | ADSS1-355HFL |
Product Overview : | Recombinant Full Length Human ADSS1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
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Description : | This gene encodes a member of the adenylosuccinate synthase family of proteins. The encoded muscle-specific enzyme plays a role in the purine nucleotide cycle by catalyzing the first step in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP). Mutations in this gene may cause adolescent onset distal myopathy. Alternative splicing results in multiple transcript variants. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 50 kDa |
AA Sequence : | MSGTRASNDRPPGAGGVKRGRLQQE AAATGSRVTVVLGAQWGDEGKGKVV DLLATDADIISRCQGGNNAG HTVVVDGKEYDFHLLPSGIINTKAV SFIGNGVVIHLPGLFEEAEKNEKKG LKDWEKRLIISDRAHLVFDF HQAVDGLQEVQRQAQEGKNIGTTKK GIGPTYSSKAARTGLRICDLLSDFD EFSSRFKNLAHQHQSMFPTL EIDIEGQLKRLKGFAERIRPMVRDG VYFMYEALHGPPKKILVEGANAALL DIDFGTYPFVTSSNCTVGGV CTGLGIPPQNIGDVYGVVKAYTTRV GIGAFPTEQINEIGGLLQTRGHEWG VTTGRKRRCGWLDLMILRYA HMVNGFTALALTKLDILDVLGEVKV GVSYKLNGKRIPYFPANQEMLQKVE VEYETLPGWKADTTGARRWE DLPPQAQNYIRFVENHVGVAVKWVG VGKSRESMIQLFTRTRPLEQKLISE EDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Pathways : | Alanine, aspartate and glutamate metabolism, Metabolic pathways, Purine metabolism |
Gene Name : | ADSS1 adenylosuccinate synthase 1 [ Homo sapiens (human) ] |
Official Symbol : | ADSS1 |
Synonyms : | MPD5; ADSSL1 |
Gene ID : | 122622 |
mRNA Refseq : | NM_152328.5 |
Protein Refseq : | NP_689541.1 |
MIM : | 612498 |
UniProt ID : | Q8N142 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionThe subcellular localization of ADSS1 protein is regulated under normal physiological conditions, with predominant cytoplasmic distribution, although it may undergo changes in response to specific cellular signals or stimuli.
ADSS1 protein is primarily involved in the de novo synthesis of purine nucleotides and plays a crucial role in the purine biosynthesis pathway.
The enzymatic activity of ADSS1 protein can be measured using assays that quantify the production or consumption of specific substrates or products involved in purine metabolism.
ADSS1 protein possesses specific structural features or domains that contribute to its enzymatic activity and substrate binding, ensuring its role in catalyzing purine biosynthesis reactions.
Post-translational modifications, such as phosphorylation or acetylation, and regulatory factors like signaling pathways or transcription factors, may modulate the activity of ADSS1 protein.
Genetic variations or mutations in the ADSS1 gene can impact the expression or function of ADSS1 protein, potentially leading to disorders related to purine metabolism.
Dysregulation or dysfunction of ADSS1 protein can disrupt cellular metabolism, particularly in purine nucleotide production, and contribute to disorders associated with purine metabolism abnormalities.
Experimental approaches, such as knockdown or overexpression studies, have been employed to investigate the functional significance of ADSS1 protein in cellular or animal models, providing insights into its roles and potential therapeutic interventions.
Techniques such as immunofluorescence and immunohistochemistry have been used to study the expression and subcellular localization of ADSS1 protein in cells or tissues.
ADSS1 protein has the potential to interact with other proteins or participate in protein complexes, which may be involved in regulating purine biosynthesis or related cellular processes.
Customer Reviews (3)
Write a reviewExploring protein-protein interactions involved in lipid metabolism.
Determining protein-protein interaction interfaces using electron microscopy.
Characterizing protein-protein interactions involved in autophagy pathways.
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