Recombinant Full Length Human ALKBH7 Protein, C-Flag-tagged

• Cat.No.: ALKBH7-2088HFL
• Product Overview: Recombinant Full Length Human ALKBH7 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Predicted to enable dioxygenase activity and metal ion binding activity. Involved in cellular response to DNA damage stimulus and regulation of mitochondrial membrane permeability involved in programmed necrotic cell death. Located in mitochondrial matrix.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 24.3 kDa
• AA Sequence: MAGTGLLALRTLPGPSWVRGSGPSV LSRLQDAAVVRPGFLSTAEEETLSR ELEPELRRRRYEYDHWDAAI HGFRETEKSRWSEASRAILQRVQAA AFGPGQTLLSSVHVLDLEARGYIKP HVDSIKFCGATIAGLSLLSP SVMRLVHTQEPGEWLELLLEPGSLY ILRGSARYDFSHEILRDEESFFGER RIPRGRRISVICRSLPEGMG PGESGQPPPAC TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.

Gene Information

• Gene Name: ALKBH7 alkB homolog 7 [ Homo sapiens (human) ]
• Official Symbol: ALKBH7
• Synonyms: ABH7; SPATA11; UNQ6002
• Gene ID: 84266
• mRNA Refseq: NM_032306.4
• Protein Refseq: NP_115682.1
• MIM: 613305
• UniProt ID: Q9BT30

Reviews

08/20/2021

Growth factor activity that promotes cell growth and proliferation.

07/14/2021

Easy to use, high stability, significant effect.

01/29/2020

It has good application performance in immunodetection, such as ELISA, Western blot, etc.

04/19/2019

Synthesized with high efficiency and yield.

Q&As

Is ALKBH7 related to the nervous system?

Yes, the ALKBH7 gene has been shown to be important for the proper maintenance of nervous system development and function.

What is the expression pattern of ALKBH7 gene?

The expression pattern of ALKBH7 gene showed broad, tissue specific and period specific.

What is the relationship between ALKBH7 gene and liver cancer?

Some studies have found that ALKBH7 gene is highly expressed in liver cancer cells and is closely related to the progression and prognosis of liver cancer.

Does mutation of ALKBH7 gene cause disease?

Yes, some studies suggest that mutations in the ALKBH7 gene may promote the development and spread of tumors and may contribute to the development of related diseases such as neurological disorders.

What is the function of the protein product of ALKBH7 gene?

The mRNA cap reader protein recognizes and binds to the 3' end of a methylated RNA molecule. Its function is to help transcription factors effectively bind to mRNA, thus promoting the normal process of protein production.

What diseases is the ALKBH7 gene associated with?

Some diseases that are known to be related to the ALKBH7 gene include liver cancer, pancreatic cancer, lung cancer, schizophrenia, and Alzheimer's disease.

What are the inhibitors of ALKBH7 gene?

At present, some inhibitors targeting ALKBH7 gene have been developed, such as plant silicates and so on.

How cellular processes does the ALKBH7 gene regulate?

ALKBH7 regulates RNA methylation and demethylation, and is involved in cellular processes such as RNA stability, transcription and translation.

In which tissues is ALKBH7 gene highly expressed?

ALKBH7 gene is highly expressed in sperm, but the expression rate of ALKBH7 gene in other tissues and cell types varies with physiological activity and different developmental stages.

Which signaling pathways does the ALKBH7 gene regulate?

ALKBH7 gene has been shown to participate in ATM/ATR signaling pathway, Wnt signaling pathway, NF-κB signaling pathway, etc.

Is the genetic mutation of ALKBH7 gene heritable?

Yes, mutations in the ALKBH7 gene are heritable.

Is ALKBH7 involved in DNA repair?

Although the ALKBH7 gene is widely expressed in multiple tissues, it has not been found to be involved in DNA repair processes, focusing on its role in RNA stability and transcription.

Is ALKBH7 involved in cancer?

Studies of the ALKBH7 gene suggest that it may be involved in some cancers and tumours, but more extensive research is needed.