Recombinant Full Length Human AP1M2 Protein, GST-tagged

• Cat.No.: AP1M2-1097HF
• Product Overview: Human AP1M2 full-length ORF ( NP_005489.2, 1 a.a. - 423 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 74.5 kDa
• Protein Length: 423 amino acids
• AA Sequence: MSASAVFILD VKGKPLISRN YKGDVAMSKI EHFMPLLVQR EEEGALAPLL SHGQVHFLWI KHSNLYLVAT TSKNANASLV YSFLYKTIEV FCEYFKELEE ESIRDNFVIV YELLDELMDF GFPQTTDSKI LQEYITQQSN KLETGKSRVP PTVTNAVSWR SEGIKYKKNE VFIDVIESVN LLVNANGSVL LSEIVGTIKL KVFLSGMPEL RLGLNDRVLF ELTGRSKNKS VELEDVKFHQ CVRLSRFDND RTISFIPPDG DFELMSYRLS TQVKPLIWIE SVIEKFSHSR VEIMVKAKGQ FKKQSVANGV EISVPVPSDA DSPRFKTSVG SAKYVPERNV VIWSIKSFPG GKEYLMRAHF GLPSVEKEEV EGRPPIGVKF EIPYFTVSGI QVRYMKIIEK SGYQALPWVR YITQSGDYQL RTS
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AP1M2 adaptor-related protein complex 1, mu 2 subunit [ Homo sapiens ]
• Official Symbol: AP1M2
• Synonyms: AP1M2; adaptor-related protein complex 1, mu 2 subunit; AP-1 complex subunit mu-2; AP1 mu2; HSMU1B; mu2; mu-adaptin 2; mu1B-adaptin; HA1 47 kDa subunit 2; AP-mu chain family member mu1B; golgi adaptor AP-1 47 kDa protein; clathrin coat assembly protein AP47 2; clathrin coat associated protein AP47 2; adaptor protein complex AP-1 mu-2 subunit; golgi adaptor HA1/AP1 adaptin mu-2 subunit; clathrin-associated adaptor medium chain mu2; adaptor-related protein complex 1 mu-2 subunit; clathrin assembly protein complex 1 medium chain 2; MU1B; MU-1B; AP1-mu2
• Gene ID: 10053
• mRNA Refseq: NM_005498
• Protein Refseq: NP_005489
• MIM: 607309
• UniProt ID: Q9Y6Q5

Reviews

02/06/2021

AP1M2 preparation cost is low and cost-effective, which is very suitable for our research.

05/06/2020

The strip locations in Western blot results were consistent with expectations, showing good target recognition capability.

10/03/2019

AP1M2 is really impressive, and the results of each experiment are very consistent, which shows that the production process is very careful.

Q&As

Is there polymorphism in AP1M2 ?

AP1M2 has polymorphism, and the expression of different polymorphisms is associated with some diseases.

Is the cost of AP1M2 synthesis relatively high?

Due to the complex structure and precision production process of AP1M2 , its synthesis cost is relatively high.

What is the biological function of AP1M2 ?

The recombinant AP1M2 protein is recognized as an aptamer and is involved in the formation and transport of cell intimal vesicles.

How to guarantee the quality of AP1M2 in the production process?

The production process of AP1M2 requires strict quality control measures, including monitoring and verification of gene cloning, protein expression, purification and other links.

What is the association between recombinant AP1M2 and autoimmune diseases?

Recombinant AP1M2 can affect the regulation of the immune system and has been linked to autoimmune diseases.

Can recombinant AP1M2 promote neurodegenerative diseases?

The abnormal expression of AP1M2 is thought to be related to the occurrence of neurodegenerative diseases.

What is the expression pattern of AP1M2 ?

Recombinant AP1M2 protein is mainly expressed in lymphoid tissue, bone marrow, spleen and stomach.

What is the position distribution of AP1M2 in the cell life cycle?

The AP1M2 is mainly concentrated in the endoplasmic reticulum and Golgi apparatus during the cell life cycle.

Which diseases are associated with recombinant AP1M2?

AP1M2 is associated with tumors, autoimmune diseases, Alzheimer's disease and other diseases.

Which genes does the AP1M2 interact with?

The AP1M2 interacts with CD8A, PEX5, VCP, STAM2 and other genes.

Can recombinant AP1M2 be used as a new means of tumor targeted therapy?

Recombinant protein AP1M2 has certain development prospects as a new means of tumor targeted therapy.

What is the effect of AP1M2 on tumor cell proliferation?

Recombinant protein AP1M2 can promote the proliferation of tumor cells, and thus promote the development and spread of tumors.

Which signaling pathways are involved in the regulation of recombinant AP1M2?

Recombinant AP1M2 protein is involved in the regulation of tumor-related signaling pathways, such as PI3K/AKT and Wnt/β-catenin signaling pathways.

Can the gene of AP1M2 be used as a tumor diagnostic marker?

The gene for the AP1M2 has been shown to be abnormally expressed in some tumors and can be used as a tumor diagnostic marker.

Is recombinant AP1M2 related to tumor stem cells?

AP1M2 is related to the formation and proliferation of tumor stem cells.

Is the use of recombinant AP1M2 limited to the treatment of tumors?

The application of AP1M2 is not limited to the treatment of tumors, but also includes neurodegenerative diseases.

Can AP1M2 be used in industrial production after immobilization?

AP1M2 can be used in industrial production after immobilization, but its limitations lie in its specific structure and application field.

Does AP1M2 affect the human immune system?

The AP1M2 is related to the regulation of the human immune system and may have a certain impact on the immune system.

Can AP1M2 be cleared by the human body?

AP1M2 can be cleared by the human body, but due to its complex molecular structure, there is still a lack of effective elimination methods.