Species : |
Human |
Source : |
In Vitro Cell Free System |
Protein Length : |
252 amino acids |
Description : |
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. |
Form : |
Liquid |
Molecular Mass : |
53.350kDa inclusive of tags |
AA Sequence : |
MFFWCACCLM VAWRVSASDE HCPELPPVDN SIFVAKEVEG QILGTYVCIK GYHLVGKKTL FCNASKEWDN TTTECRLGHC PDPVLVNGEF SSSGPVNVSD KITFMCNDHY ILKGSNRSQC LEDHTWAPPF PICKSRDCDP PGNPVHGYFE GNNFTLGSTI SYYCEDRYYL VGVQEQQCVD GEWSSALPVC KLIQEAPKPE CEKALLAFQE SKNLCEAMEN FMQQLKESGM TMEELKYSLE LKKAELKAKL L |
Purity : |
Proprietary Purification |
Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles. |
Storage Buffer : |
pH: 8.00. Constituents: 0.3% Glutathione, 0.79% Tris HCl. |