Human C4BPB Knockdown Cell Lysate

• Cat.No.: C4BPB-472HKCL
• Product Overview: WB-validated C4BPB Knockdown HepG2 Cell Lysate

Specification

• Species: Human
• Source: HepG2
• Tag: Non
• Description: This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 28 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HepG2 cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HepG2 cell lysate 1 vial of 100 μg C4BPB KD HepG2 cell lysate
• Protein Pathways: Complement and coagulation cascades
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: C4BPB complement component 4 binding protein, beta [ Homo sapiens (human) ]
• Official Symbol: C4BPB
• Synonyms: C4BPB; complement component 4 binding protein, beta; C4BP, complement component 4 binding protein, beta; C4b-binding protein beta chain; C4b binding protein; beta chain; complement component 4 binding protein; C4BP
• Gene ID: 725
• mRNA Refseq: NM_000716
• Protein Refseq: NP_000707
• MIM: 120831
• UniProt ID: P20851