| Description : |
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
GST |
| Molecular Mass : |
The protein has a calculated MW of 48 kDa. |
| AA Sequence : |
MSPILGYWKIKGLVQPTRLLLEYLE EKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYIDGDVKLTQSMAIIRYI ADKHNMLGGCPKERAEISMLEGAVL DIRYGVSRIAYSKDFETLKVDFLSK LPEMLKMFEDRLCHKTYLNGDHVTH PDFMLYDALDVVLYMDPMCLDAFPK LVCFKKRIEAIPQIDKYLKSSKYIA WPLQGWQATFGGGDHPPKSDGSTSG SGHHHHHHSAGLVPRGSTAIGMKET AAAKFERQHMDSPDLGTGGGSGDDD DKSPMVRLPLQCVLWGCLLTAVHPE PPTACREKQYLINSQCCSLCQPGQK LVSDCTEFTETECLPCGESEFLDTW NRETHFHQHKYCDPNLGLRVQQKGT SETDTICTCEEGWHCTSEACESCVL HRSCSPGFGVKQIDICQPHFPKDRG LNLLM |
| Purity : |
> 90% by SDS-PAGE |
| Storage : |
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Concentration : |
1.01 mg/mL by BCA |
| Storage Buffer : |
Sterile 20 mM Tris, 200 mM NaCl, 5 mM EDTA, pH 8.0 |
