Recombinant Full Length Human CGAS Protein, C-Flag-tagged

• Cat.No.: CGAS-165HFL
• Product Overview: Recombinant Full Length Human CGAS Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Enables several functions, including 2',3'-cyclic GMP-AMP synthase activity; chromatin binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to exogenous dsRNA; positive regulation of intracellular signal transduction; and regulation of defense response. Located in several cellular components, including cytosol; nucleus; and site of double-strand break.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 58.6 kDa
• AA Sequence: MQPWHGKAMQRASEAGATAPKASAR NARGAPMDPNESPAAPEAALPKAGK FGPARKSGSRQKKSAPDTQE RPPVRATGARAKKAPQRAQDTQPSD ATSAPGAEGLEPPAAREPALSRAGS CRQRGARCSTKPRPPPGPWD VPSPGLPVSAPILVRRDAAPGASKL RAVLEKLKLSRDDISTAAGMVKGVV DHLLLRLKCDSAFRGVGLLN TGSYYEHVKISAPNEFDVMFKLEVP RIQLEEYSNTRAYYFVKFKRNPKEN HLSQFLEGEILSASKMLSKF RKIIKEEINDIKDTDVIMKRKRGGS PAVTLLISEKISVDITLALESKSSW PASTQEGLRIQNWLSAKVRK QLRLKPFYLVPKHAKEGNGFQEETW RLSFSHIEKEILNNHGKSKTCCENK EEKCCRKDCLKLMKYLLEQL KERFKDKKHLDKFSSYHVKTAFFHV CTQNPQDSQWDRKDLGLCFDNCVTY FLQCLRTEKLENYFIPEFNL
  FSSNLIDKRSKEFLTKQIEYERNNE FPVFDEFTRTRPLEQKLISEEDLAA NDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.

Gene Information

• Gene Name: CGAS cyclic GMP-AMP synthase [ Homo sapiens (human) ]
• Official Symbol: CGAS
• Synonyms: MB21D1; h-cGAS; C6orf150
• Gene ID: 115004
• mRNA Refseq: NM_138441.3
• Protein Refseq: NP_612450.2
• MIM: 613973
• UniProt ID: Q8N884