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Recombinant Full Length Human EPCAM Protein, C-Flag-tagged

Cat.No. : EPCAM-1391HFL
Product Overview : Recombinant Full Length Human EPCAM Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 32.7 kDa
AA Sequence : MAPPQVLAFGLLLAAATATFAAAQE ECVCENYKLAVNCFVNNNRQCQCTS VGAQNTVICSKLAAKCLVMK AEMNGSKLGRRAKPEGALQNNDGLY DPDCDESGLFKAKQCNGTSTCWCVN TAGVRRTDKDTEITCSERVR TYWIIIELKHKAREKPYDSKSLRTA LQKEITTRYQLDPKFITSILYENNV ITIDLVQNSSQKTQNDVDIA DVAYYFEKDVKGESLFHSKKMDLTV NGEQLDLDPGQTLIYYVDEKAPEFS MQGLKAGVIAVIVVVVIAVV
AGIVVLVISRKKRMAKYEKAEIKEM GEMHRELNATRRLEQKLISEEDLAA NDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : ES Cell Differentiation/IPS, Transmembrane
Gene Name : EPCAM epithelial cell adhesion molecule [ Homo sapiens (human) ]
Official Symbol : EPCAM
Synonyms : ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; BerEp4; EGP314; HNPCC8; LYNCH8; MOC-31; Ber-Ep4; TACSTD1
Gene ID : 4072
mRNA Refseq : NM_002354.3
Protein Refseq : NP_002345.2
MIM : 185535
UniProt ID : P16422

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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In which types of tissues is EpCAM predominantly expressed? 12/07/2022

EpCAM is highly expressed in epithelial tissues and some cancer cells.

How does EpCAM contribute to cell adhesion? 08/21/2022

It has a controversial role in cell adhesion, possibly contributing to both cell-cell adhesion and anti-adhesive properties.

What is the primary function of EpCAM in cells? 04/16/2022

EpCAM primarily functions in cell signaling, proliferation, and migration.

What role does EpCAM play in cancer progression? 03/19/2022

It often has a pro-tumorigenic role, promoting cancer cell proliferation, migration, and invasion.

How is EpCAM used as a biomarker in cancer diagnosis? 03/28/2021

EpCAM is used as a biomarker to detect and isolate circulating tumor cells.

What therapeutic strategies are being explored involving EpCAM? 11/23/2018

Strategies include developing EpCAM-targeted therapies for cancer treatment.

Are there known genetic alterations in EpCAM associated with specific health conditions? 11/07/2018

Genetic alterations in EpCAM are linked to some hereditary cancer syndromes.

Customer Reviews (3)

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Reviews
02/13/2022

    Reliable for assays, satisfied customer.

    09/09/2019

      High-quality product, consistent results.

      04/03/2019

        Quick delivery, product as described.

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