Recombinant Full Length Human HLA-DPA1 Protein, GST&His tagged

• Cat.No.: HLA-DPA1-08HFL
• Product Overview: Purified recombinant protein of Human major hist centigradeompatibility complex, class II, DP alpha 1 (HLA-DPA1), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: GST&His
• Protein Length: 1-260 aa
• Description: HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymph centigradeytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
• Form: 50 mM Tris-HCl, pH 8.0, 8 M urea
• Molecular Mass: 54.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration pr centigradeess.
• Storage: Store at -80 centigrade. Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Concentration: > 0.05 μg/μL as determined by microplate BCA method

Gene Information

• Gene Name: HLA-DPA1 major hist centigradeompatibility complex, class II, DP alpha 1 [ Homo sapiens (human) ]
• Official Symbol: HLA-DPA1
• Synonyms: HLA-DPA1; major hist centigradeompatibility complex, class II, DP alpha 1; HLA DP1A; HLA class II hist centigradeompatibility antigen, DP alpha 1 chain; MHC class II DPA1; HLA-SB alpha chain; MHC class II antigen; MHC class II DP3-alpha; Primed lymph centigradeyte test-1; MHC class II HLA-DPA1 antigen; HLA class II hist centigradeompatibility antigen, DP alpha chain; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DP1A
• Gene ID: 3113
• mRNA Refseq: NM_033554
• Protein Refseq: NP_291032
• MIM: 142880
• UniProt ID: P20036