Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Full Length Human IGF1R Protein, C-Flag-tagged

Cat.No. : IGF1R-453HFL
Product Overview : Recombinant Full Length Human IGF1R Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
  • Specification
  • Gene Information
  • Related Products
Description : This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 81 kDa
AA Sequence : MKSGSGGGSPTSLWGLLFLSAALSL WPTSGEICGPGIDIRNDYQQLKRLE NCTVIEGYLHILLISKAEDY RSYRFPKLTVITEYLLLFRVAGLES LGDLFPNLTVIRGWKLFYNYALVIF EMTNLKDIGLYNLRNITRGA IRIEKNADLCYLSTVDWSLILDAVS NNYIVGNKPPKECGDLCPGTMEEKP MCEKTTINNEYNYRCWTTNR CQKMCPSTCGKRACTENNECCHPEC LGSCSAPDNDTACVACRHYYYAGVC VPACPPNTYRFEGWRCVDRD FCANILSAESSDSEGFVIHDGECMQ ECPSGFIRNGSQSMYCIPCEGPCPK VCEEEKKTKTIDSVTSAQML QGCTIFKGNLLINIRRGNNIASELE NFMGLIEVVTGYVKIRHSHALVSLS FLKNLRLILGEEQLEGNYSF YVLDNQNLQQLWDWDHRNLTIKAGK MYFAFNPKLCVSEIYRMEEVTGTKG RQSKGDINTRNNGERASCES DVLHFTSTTTSKNRIIITWHRYRPP DYRDLISFTVYYKEAPFKNVTEYDG QDACGSNSWNMVDVDLPPNK DVEPGILLHGLKPWTQYAVYVKAVT LTMVENDHIRGAKSEILYIRTNASV PSIPLDVLSASNSSSQLIVK WNPPSLPNGNLSYYIVRWQRQPQDG YLYRHNYCSKDKIPIRKYADGTIDI EEVTENPKTEVCGGEKGPCC ACPKTEAEKQAEKEEAEYRKVFENF LHNSIFVPRPERKRRDVMQVANTTM SSRSRNTTAADTYNITDPEE LETEYPFFESRVDNKERTVISNLRP FTLYRIDIHSCNHEAEKLGCSASNF VFARTMPAEGADDIPGPVTW EPRPENSIFLKWPEPENPNGLILMY EIKYGSQVEDQRECVSRQEYRKYGG AKLNRLNPGNYTARIQATSL SGNGSWTDPVFFYVQAKTGYENFIH LIIALPVAVLLIVGGLVIMLYVFHR KRNNSRLGNGVLYASVNPEY FSAADVYVPDEWEVAREKITMSREL GQGSFGMVYEGVAKGVVKDEPETRV AIKTVNEAASMRERIEFLNE ASVMKEFNCHHVVRLLGVVSQGQPT LVIMELMTRGDLKSYLRSLRPEMEN NPVLAPPSLSKMIQMAGEIA DGMAYLNANKFVHRDLAARNCMVAE DFTVKIGDFGMTRDIYETDYYRKGG KGLLPVRWMSPESLKDGVFT TYSDVWSFGVVLWEIATLAEQPYQG LSNEQVLRFVMEGGLLDKPDNCPDM LFELMRMCWQYNPKMRPSFL EIISSIKEEMEPGFREVSFYYSEEN KLPEPEELDLEPENMESVPLDPSAS SSSLPLPDRHSGHKAENGPG
PGVLVLRASFDERQPYAHMNGGRKN ERALPLPQSSTCTRTRPLEQKLISE EDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways : Adherens junction, Colorectal cancer, Endocytosis, Focal adhesion, Glioma, Long-term depression, Melanoma, Oocyte meiosis, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer
Gene Name : IGF1R insulin like growth factor 1 receptor [ Homo sapiens (human) ]
Official Symbol : IGF1R
Synonyms : IGFR; CD221; IGFIR; JTK13
Gene ID : 3480
mRNA Refseq : NM_000875.5
Protein Refseq : NP_000866.1
MIM : 147370
UniProt ID : P08069

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends