Recombinant Full Length Human IGF1R Protein, C-Flag-tagged

• Cat.No.: IGF1R-453HFL
• Product Overview: Recombinant Full Length Human IGF1R Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 81 kDa
• AA Sequence: MKSGSGGGSPTSLWGLLFLSAALSL WPTSGEICGPGIDIRNDYQQLKRLE NCTVIEGYLHILLISKAEDY RSYRFPKLTVITEYLLLFRVAGLES LGDLFPNLTVIRGWKLFYNYALVIF EMTNLKDIGLYNLRNITRGA IRIEKNADLCYLSTVDWSLILDAVS NNYIVGNKPPKECGDLCPGTMEEKP MCEKTTINNEYNYRCWTTNR CQKMCPSTCGKRACTENNECCHPEC LGSCSAPDNDTACVACRHYYYAGVC VPACPPNTYRFEGWRCVDRD FCANILSAESSDSEGFVIHDGECMQ ECPSGFIRNGSQSMYCIPCEGPCPK VCEEEKKTKTIDSVTSAQML QGCTIFKGNLLINIRRGNNIASELE NFMGLIEVVTGYVKIRHSHALVSLS FLKNLRLILGEEQLEGNYSF YVLDNQNLQQLWDWDHRNLTIKAGK MYFAFNPKLCVSEIYRMEEVTGTKG RQSKGDINTRNNGERASCES DVLHFTSTTTSKNRIIITWHRYRPP DYRDLISFTVYYKEAPFKNVTEYDG QDACGSNSWNMVDVDLPPNK DVEPGILLHGLKPWTQYAVYVKAVT LTMVENDHIRGAKSEILYIRTNASV PSIPLDVLSASNSSSQLIVK WNPPSLPNGNLSYYIVRWQRQPQDG YLYRHNYCSKDKIPIRKYADGTIDI EEVTENPKTEVCGGEKGPCC ACPKTEAEKQAEKEEAEYRKVFENF LHNSIFVPRPERKRRDVMQVANTTM SSRSRNTTAADTYNITDPEE LETEYPFFESRVDNKERTVISNLRP FTLYRIDIHSCNHEAEKLGCSASNF VFARTMPAEGADDIPGPVTW EPRPENSIFLKWPEPENPNGLILMY EIKYGSQVEDQRECVSRQEYRKYGG AKLNRLNPGNYTARIQATSL SGNGSWTDPVFFYVQAKTGYENFIH LIIALPVAVLLIVGGLVIMLYVFHR KRNNSRLGNGVLYASVNPEY FSAADVYVPDEWEVAREKITMSREL GQGSFGMVYEGVAKGVVKDEPETRV AIKTVNEAASMRERIEFLNE ASVMKEFNCHHVVRLLGVVSQGQPT LVIMELMTRGDLKSYLRSLRPEMEN NPVLAPPSLSKMIQMAGEIA DGMAYLNANKFVHRDLAARNCMVAE DFTVKIGDFGMTRDIYETDYYRKGG KGLLPVRWMSPESLKDGVFT TYSDVWSFGVVLWEIATLAEQPYQG LSNEQVLRFVMEGGLLDKPDNCPDM LFELMRMCWQYNPKMRPSFL EIISSIKEEMEPGFREVSFYYSEEN KLPEPEELDLEPENMESVPLDPSAS SSSLPLPDRHSGHKAENGPG
  PGVLVLRASFDERQPYAHMNGGRKN ERALPLPQSSTCTRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Adherens junction, Colorectal cancer, Endocytosis, Focal adhesion, Glioma, Long-term depression, Melanoma, Oocyte meiosis, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer

Gene Information

• Gene Name: IGF1R insulin like growth factor 1 receptor [ Homo sapiens (human) ]
• Official Symbol: IGF1R
• Synonyms: IGFR; CD221; IGFIR; JTK13
• Gene ID: 3480
• mRNA Refseq: NM_000875.5
• Protein Refseq: NP_000866.1
• MIM: 147370
• UniProt ID: P08069