Recombinant Full Length Human Insulin-Like Growth Factor 1 Receptor(Igf1R) Protein, His-Tagged
Cat.No. : | RFL3772HF |
Product Overview : | Recombinant Full Length Human Insulin-like growth factor 1 receptor(IGF1R) Protein (P08069) (31-736aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Homo sapiens (Human) |
Tag : | His |
Form : | Lyophilized powder |
Protein length : | Full Length (31-736) |
AA Sequence : | EICGPGIDIRNDYQQLKRLENCTVI EGYLHILLISKAEDYRSYRFPKLTV ITEYLLLFRVAGLESLGDLFPNLTV IRGWKLFYNYALVIFEMTNLKDIGL YNLRNITRGAIRIEKNADLCYLSTV DWSLILDAVSNNYIVGNKPPKECGD LCPGTMEEKPMCEKTTINNEYNYRC WTTNRCQKMCPSTCGKRACTENNEC CHPECLGSCSAPDNDTACVACRHYY YAGVCVPACPPNTYRFEGWRCVDRD FCANILSAESSDSEGFVIHDGECMQ ECPSGFIRNGSQSMYCIPCEGPCPK VCEEEKKTKTIDSVTSAQMLQGCTI FKGNLLINIRRGNNIASELENFMGL IEVVTGYVKIRHSHALVSLSFLKNL RLILGEEQLEGNYSFYVLDNQNLQQ LWDWDHRNLTIKAGKMYFAFNPKLC VSEIYRMEEVTGTKGRQSKGDINTR NNGERASCESDVLHFTSTTTSKNRI IITWHRYRPPDYRDLISFTVYYKEA PFKNVTEYDGQDACGSNSWNMVDVD LPPNKDVEPGILLHGLKPWTQYAVY VKAVTLTMVENDHIRGAKSEILYIR TNASVPSIPLDVLSASNSSSQLIVK WNPPSLPNGNLSYYIVRWQRQPQDG YLYRHNYCSKDKIPIRKYADGTIDI EEVTENPKTEVCGGEKGPCCACPKT EAEKQAEKEEAEYRKVFENFLHNSI FVPRPERKRRDVMQVANTTMSSRSR NTTAADTYNIT |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Applications : | SDS-PAGE |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | IGF1R |
Synonyms : | CD221; CD221 antigen ; IGF 1 receptor; IGF 1R; IGF I receptor; IGF-I receptor; Igf1r; IGF1R_HUMAN; IGFIR; IGFIRC; IGFR; Insulin like growth factor 1 receptor; Insulin like growth factor 1 receptor precursor; Insulin-like growth factor 1 receptor beta chai |
UniProt ID : | P08069 |
Gene Name : | IGF1R |
Synonyms : | CD221; CD221 antigen ; IGF 1 receptor; IGF 1R; IGF I receptor; IGF-I receptor; Igf1r; IGF1R_HUMAN; IGFIR; IGFIRC; IGFR; Insulin like growth factor 1 receptor; Insulin like growth factor 1 receptor precursor; Insulin-like growth factor 1 receptor beta chai |
UniProt ID : | P08069 |
Products Types
◆ Recombinant Protein | ||
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IGF1R-1391H | Recombinant Human IGF1R Protein, DDK-tagged | +Inquiry |
IGF1R-299H | Recombinant Human IGF1R Protein, His and Strep-tagged | +Inquiry |
IGF1R-1399C | Recombinant Cynomolgus IGF1R protein, His-tagged | +Inquiry |
◆ Lysates | ||
IGF1R-2928HCL | Recombinant Human IGF1R cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1600 | IGF1R Functional Assay Kit | +Inquiry |
Kit-1601 | HEK 293 IGF1R Bioassay Kit | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe product's exceptional purity facilitated precise quantification, ensuring data consistency.
The product consistently delivered robust and dependable results, affirming its efficacy in our experiments.
The product's consistent performance bolstered the dependability of our research conclusions.
Q&As (7)
Ask a questionIGF1R is predominantly localized on the cell membrane, where it acts as a receptor for insulin-like growth factors (IGFs) and insulin.
Downstream signaling pathways activated by IGF1R include the Ras/MAPK pathway and PI3K/Akt pathway, contributing to cell growth and survival.
IGF1R interacts with IGFs and insulin, triggering downstream signaling pathways such as the PI3K/Akt pathway, influencing cell proliferation and survival.
There are potential therapeutic implications related to IGF1R in diseases involving growth signaling, making it a target for drug development.
Dysregulation or abnormal expression of IGF1R is associated with conditions such as cancer and developmental disorders.
Insulin-like growth factor 1 receptor (IGF1R) functions in cellular processes, primarily playing a role in growth signaling.
IGF1R contributes to the regulation of tissue development by influencing cell growth, differentiation, and survival.
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