Recombinant Rat Igf1r protein, His-tagged

• Cat.No.: Igf1r-30R
• Product Overview: Recombinant Rat Igf1r(Tyr764~Leu956) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: Igf1r played an important role in many functions.
• Source: E. coli
• Species: Rat
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 25.7kDa
• Protein length: Tyr764~Leu956
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >90%
• Applications: SDS-PAGE; WB; ELISA; IP
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: Igf1r insulin-like growth factor 1 receptor [ Rattus norvegicus ]
• Official Symbol: Igf1r
• Synonyms: IGF1R; insulin-like growth factor 1 receptor; IGF-I receptor; insulin-like growth factor I receptor; JTK13; IGFIRC
• Gene ID: 25718
• mRNA Refseq: NM_052807
• Protein Refseq: NP_434694
• UniProt ID: P24062
• Chromosome Location: 1q22
• Pathway: Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Apoptosis, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Focal adhesion, organism-specific biosystem
• Function: ATP binding; G-protein alpha-subunit binding; identical protein binding; identical protein binding; insulin binding; insulin binding; insulin receptor binding; insulin receptor binding; insulin receptor substrate binding; insulin receptor substrate binding; insulin receptor substrate binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor I binding; insulin-like growth factor binding; insulin-like growth factor binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; insulin-like growth factor-activated receptor activity; insulin-like growth factor-activated receptor activity; nucleotide binding; phosphatidylinositol 3-kinase binding; phosphatidylinositol 3-kinase binding; phosphatidylinositol 3-kinase binding; protein tyrosine kinase activity; protein tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity

Reviews

07/08/2022

The product's exceptional purity facilitated precise quantification, ensuring data consistency.

06/14/2019

The product consistently delivered robust and dependable results, affirming its efficacy in our experiments.

04/29/2018

The product's consistent performance bolstered the dependability of our research conclusions.

Q&As

In which cellular compartments is IGF1R predominantly localized?

IGF1R is predominantly localized on the cell membrane, where it acts as a receptor for insulin-like growth factors (IGFs) and insulin.

Are there specific downstream signaling pathways activated by IGF1R, and how do they influence cell proliferation and survival?

Downstream signaling pathways activated by IGF1R include the Ras/MAPK pathway and PI3K/Akt pathway, contributing to cell growth and survival.

How does IGF1R interact with insulin-like growth factors (IGFs) and insulin, and what is its role in growth regulation?

IGF1R interacts with IGFs and insulin, triggering downstream signaling pathways such as the PI3K/Akt pathway, influencing cell proliferation and survival.

Are there therapeutic implications or potential targets related to IGF1R in diseases involving growth signaling?

There are potential therapeutic implications related to IGF1R in diseases involving growth signaling, making it a target for drug development.

What diseases or conditions are associated with dysregulation or abnormal expression of IGF1R?

Dysregulation or abnormal expression of IGF1R is associated with conditions such as cancer and developmental disorders.

What is the primary function of Insulin-like growth factor 1 receptor (IGF1R) in cellular processes and growth signaling?

Insulin-like growth factor 1 receptor (IGF1R) functions in cellular processes, primarily playing a role in growth signaling.

How does IGF1R contribute to the regulation of tissue development, particularly in the context of growth and differentiation?

IGF1R contributes to the regulation of tissue development by influencing cell growth, differentiation, and survival.