Recombinant Full Length Human KIR2DS2 Protein, C-Flag-tagged

• Cat.No.: KIR2DS2-1497HFL
• Product Overview: Recombinant Full Length Human KIR2DS2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene represents a haplotype-specific family member that encodes a protein with a short cytoplasmic tail. Alternative splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 31.5 kDa
• AA Sequence: MSLTVVSMACVGFFLLQGAWPHEGV HRKPSLLAHPGPLVKSEETVILQCW SDVRFEHFLLHREGKYKDTL HLIGEHHDGVSKANFSIGPMMQDLA GTYRCYGSVTHSPYQLSAPSDPLDI VITGLYEKPSLSAQPGPTVL AGESVTLSCSSRSSYDMYHLSREGE AHERRFSAGPKVNGTFQADFPLGPA THGGTYRCFGSFRDSPYEWS NSSDPLLVSVTGNPSNSWPSPTEPS SKTGNPRHLHVLIGTSVVKIPFTIL LFFLLHRWCSNKKNAAVMDQ
  EPAGNRTVNSEDSDEQDHQEVSYAT RTRPLEQKLISEEDLAANDILDYKD DDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.

Gene Information

• Gene Name: KIR2DS2 killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 [ Homo sapiens (human) ]
• Official Symbol: KIR2DS2
• Synonyms: NKAT5; cl-49; CD158J; CD158b; NKAT-5; 183ActI; KIR2DL1; KIR-2DS2
• Gene ID: 100132285
• mRNA Refseq: NM_012312.4
• Protein Refseq: NP_036444.1
• UniProt ID: P43631