Recombinant Full Length Human KLHL3 Protein, C-Flag-tagged
Cat.No. : | KLHL3-1136HFL |
Product Overview : | Recombinant Full Length Human KLHL3 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 64.8 kDa |
AA Sequence : | MEGESVKLSSQTLIQAGDDEKNQRT ITVNPAHMGKAFKVMNELRSKQLLC DVMIVAEDVEIEAHRVVLAA CSPYFCAMFTGDMSESKAKKIEIKD VDGQTLSKLIDYIYTAEIEVTEENV QVLLPAASLLQLMDVRQNCC DFLQSQLHPTNCLGIRAFADVHTCT DLLQQANAYAEQHFPEVMLGEEFLS LSLDQVCSLISSDKLTVSSE EKVFEAVISWINYEKETRLEHMAKL MEHVRLPLLPRDYLVQTVEEEALIK NNNTCKDFLIEAMKYHLLPL DQRLLIKNPRTKPRTPVSLPKVMIV VGGQAPKAIRSVECYDFEEDRWDQI AELPSRRCRAGVVFMAGHVY AVGGFNGSLRVRTVDVYDGVKDQWT SIASMQERRSTLGAAVLNDLLYAVG GFDGSTGLASVEAYSYKTNE WFFVAPMNTRRSSVGVGVVEGKLYA VGGYDGASRQCLSTVEQYNPATNEW IYVADMSTRRSGAGVGVLSG QLYATGGHDGPLVRKSVEVYDPGTN TWKQVADMNMCRRNAGVCAVNGLLY VVGGDDGSCNLASVEYYNPV TDKWTLLPTNMSTGRSYAGVAVIHK SLTRTRPLEQKLISEEDLAANDILD YKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Gene Name : | KLHL3 kelch like family member 3 [ Homo sapiens (human) ] |
Official Symbol : | KLHL3 |
Synonyms : | PHA2D |
Gene ID : | 26249 |
mRNA Refseq : | NM_017415.3 |
Protein Refseq : | NP_059111.2 |
MIM : | 605775 |
UniProt ID : | Q9UH77 |
Products Types
◆ Recombinant Protein | ||
KLHL3-1240H | Recombinant Human KLHL3 Protein (E2-L587), His/Strep tagged | +Inquiry |
KLHL3-2249R | Recombinant Rhesus Macaque KLHL3 Protein, His (Fc)-Avi-tagged | +Inquiry |
KLHL3-1254H | Recombinant Human KLHL3 Protein, His (Fc)-Avi-tagged | +Inquiry |
KLHL3-1239H | Recombinant Human KLHL3 Protein (E2-L587), Tag Free | +Inquiry |
KLHL3-2428R | Recombinant Rhesus monkey KLHL3 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
KLHL3-4908HCL | Recombinant Human KLHL3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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