Recombinant Full Length Human LINGO1 Protein, C-Flag-tagged

• Cat.No.: LINGO1-349HFL
• Product Overview: Recombinant Full Length Human LINGO1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within generation of neurons and protein kinase B signaling. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Implicated in autosomal recessive non-syndromic intellectual disability and glaucoma.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 69.7 kDa
• AA Sequence: MQVSKRMLAGGVRSMPSPLLACWQP ILLLVLGSVLSGSATGCPPRCECSA QDRAVLCHRKRFVAVPEGIP TETRLLDLGKNRIKTLNQDEFASFP HLEELELNENIVSAVEPGAFNNLFN LRTLGLRSNRLKLIPLGVFT GLSNLTKLDISENKIVILLDYMFQD LYNLKSLEVGDNDLVYISHRAFSGL NSLEQLTLEKCNLTSIPTEA LSHLHGLIVLRLRHLNINAIRDYSF KRLYRLKVLEISHWPYLDTMTPNCL YGLNLTSLSITHCNLTAVPY LAVRHLVYLRFLNLSYNPISTIEGS MLHELLRLQEIQLVGGQLAVVEPYA FRGLNYLRVLNVSGNQLTTL EESVFHSVGNLETLILDSNPLACDC RLLWVFRRRWRLNFNRQQPTCATPE FVQGKEFKDFPDVLLPNYFT CRRARIRDRKAQQVFVDEGHTVQFV CRADGDPPPAILWLSPRKHLVSAKS NGRLTVFPDGTLEVRYAQVQ DNGTYLCIAANAGGNDSMPAHLHVR SYSPDWPHQPNKTFAFISNQPGEGE ANSTRATVPFPFDIKTLIIA
  TTMGFISFLGVVLFCLVLLFLWSRG KGNTKHNIEIEYVPRKSDAGISSAD APRKFNMKMITRTRPLEQKLISEED LAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane

Gene Information

• Gene Name: LINGO1 leucine rich repeat and Ig domain containing 1 [ Homo sapiens (human) ]
• Official Symbol: LINGO1
• Synonyms: LERN1; MRT64; LRRN6A; UNQ201
• Gene ID: 84894
• mRNA Refseq: NM_032808.7
• Protein Refseq: NP_116197.4
• MIM: 609791
• UniProt ID: Q96FE5