Recombinant Full Length Human MGLL Protein, C-Flag-tagged

• Cat.No.: MGLL-730HFL
• Product Overview: Recombinant Full Length Human MGLL Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 34.1 kDa
• AA Sequence: METGPEDPSSMPEESSPRRTPQSIP YQDLPHLVNADGQYLFCRYWKPTGT PKALIFVSHGAGEHSGRYEE LARMLMGLDLLVFAHDHVGHGQSEG ERMVVSDFHVFVRDVLQHVDSMQKD YPGLPVFLLGHSMGGAIAIL TAAERPGHFAGMVLISPLVLANPES ATTFKVLAAKVLNLVLPNLSLGPID SSVLSRNKTEVDIYNSDPLI CRAGLKVCFGIQLLNAVSRVERALP KLTVPFLLLQGSADRLCDSKGAYLL MELAKSQDKTLKIYEGAYHV
  LHKELPEVTNSVFHEINMWVSQRTA TAGTASPPTRTRPLEQKLISEEDLA ANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protease
• Protein Pathways: Glycerolipid metabolism, Metabolic pathways

Gene Information

• Gene Name: MGLL monoglyceride lipase [ Homo sapiens (human) ]
• Official Symbol: MGLL
• Synonyms: MGL; HUK5; MAGL; HU-K5
• Gene ID: 11343
• mRNA Refseq: NM_007283.7
• Protein Refseq: NP_009214.1
• MIM: 609699
• UniProt ID: Q99685