| Description : |
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Tag : |
GST |
| Molecular Mass : |
80.9 kDa |
| Protein Length : |
471 amino acids |
| AA Sequence : |
MENLKHIITLGQVIHKRCEEMKYCK KQCRRLGHRVLGLIKPLEMLQDQGK RSVPSEKLTTAMNRFKAALEEANGE IEKFSNRSNICRFLTASQDKILFKD VNRKLSDVWKELSLLLQVEQRMPVS PISQGASWAQEDQQDADEDRRAFQM LRRDNEKIEASLRRLEINMKEIKET LRQYLPPKCMQEIPQEQIKEIKKEQ LSGSPWILLRENEVSTLYKGEYHRA PVAIKVFKKLQAGSIAIVRQTFNKE IKTMKKFESPNILRIFGICIDETVT PPQFSIVMEYCELGTLRELLDREKD LTLGKRMVLVLGAARGLYRLHHSEA PELHGKIRSSNFLVTQGYQVKLAGF ELRKTQTSMSLGTTREKTDRVKSTA YLSPQELEDVFYQYDVKSEIYSFGI VLWEIATGDIPFQGCNSEKIRKLVA VKRQQEPLGEDCPSELREIIDECRA HDPSVRPSVDEILKKLSTFSK |
| Applications : |
ELISA; WB-Re; AP; Array |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCl, 10 mM reduced Glutathione, pH 8.0 in the elution buffer. |
