Recombinant Mouse Mlkl protein, His-tagged MLKL-9880M

Recombinant Mouse Mlkl protein, His-tagged

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Recombinant Mouse Mlkl protein, His-tagged

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Cat.No. : MLKL-9880M
Product Overview : Recombinant Mouse Mlkl(1-472aa) fused with His tag was expressed in HEK293.
Description : This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene.
Source : HEK293
Species : Mouse
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 56.3kD
Protein length : 1-472aa
AA Sequence : MDKLGQIIKLGQLIYEQCEKMKYCRKQCQRLGNRVHGLLQPLQRLQAQGKKNLPDDITAALGRFDEVLKEANQQI EKFSKKSHIWKFVSVGNDKILFHEVNEKLRDVWEELLLLLQVYHWNTVSDVSQPASWQQEDRQDAEEDGNENMKV ILMQLQISVEEINKTLKQCSLKPTQEIPQDLQIKEIPKEHLGPPWTKLKTSKMSTIYRGEYHRSPVTIKVFNNPQ AESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVL RAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCL YDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGRS LSGRERILERLSAVEESTDKKV
Purity : >90% ( SDS-PAGE )
Storage : Store at -20 centigrade for extended storage conserve at -20 centigrade or -80 centigrade. Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Gene Name : Mlkl mixed lineage kinase domain-like [ Mus musculus ]
Official Symbol : Mlkl
Synonyms : MLKL; mixed lineage kinase domain-like; mixed lineage kinase domain-like protein; 9130019I15Rik;
Gene ID : 74568
mRNA Refseq : NM_029005
Protein Refseq : NP_083281
UniProt ID : Q9D2Y4
Chromosome Location : 8; 8 D3
Function : ATP binding; protein kinase activity; transferase activity, transferring phosphorus-containing groups;

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