| Description : |
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Form : |
Liquid |
| Molecular Mass : |
128.590kDa inclusive of tags |
| Protein Length : |
935 amino acids |
| AA Sequence : |
MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAI LQVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESE VMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAP EKDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETG VPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTA HLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINY VPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTV AMLMQSTVESAKRFLEKFKPGKWMIQYNNLNLKTPVPSDI DISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSAL ERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAH LYQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNL HLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLV PSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFAR LDIDPETITWQRVLDTNDRFLRKITIGQAPTEKGHTRTAQ FDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPV SAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFA NIAHGNSSIIADQIALKLVGPEGFVVTEAGFGADIGMEKF FNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLP KAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFK TDTESELDLISRLSREHGAFDAVKCTHWAEGGKGALALAQ AVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIE LLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGV PTGFILPIRDIRASVGAGFLYPLVGTMSTMPGLPTRPCFY DIDLDPETEQVNGLF |
| Purity : |
Proprietary Purification |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles. |
| Storage Buffer : |
pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione. |
