Recombinant Full Length Human RNF2 Protein, C-Flag-tagged

• Cat.No.: RNF2-941HFL
• Product Overview: Recombinant Full Length Human RNF2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 37.5 kDa
• AA Sequence: MSQAVQTNGTQPLSKTWELSLYELQ RTPQEAITDGLEIVVSPRSLHSELM CPICLDMLKNTMTTKECLHR FCADCIITALRSGNKECPTCRKKLV SKRSLRPDPNFDALISKIYPSRDEY EAHQERVLARINKHNNQQAL SHSIEEGLKIQAMNRLQRGKKQQIE NGSGAEDNGDSSHCSNASTHSNQEA GPSNKRTKTSDDSGLELDNN NAAMAIDPVMDGASEIELVFRPHPT LMEKDDSAQTRYIKTSGNATVDHLS KYLAVRLALEELRSKGESNQ
  MNLDTASEKQYTIYIATASGQFTVL NGSFSLELVSEKYWKVNKPMELYYA PTKEHKTRTRPLEQKLISEEDLAAN DILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors

Gene Information

• Gene Name: RNF2 ring finger protein 2 [ Homo sapiens (human) ]
• Official Symbol: RNF2
• Synonyms: BAP1; DING; BAP-1; HIPI3; RING2; LUSYAM; RING1B
• Gene ID: 6045
• mRNA Refseq: NM_007212.4
• Protein Refseq: NP_009143.1
• MIM: 608985
• UniProt ID: Q99496