Recombinant Full Length Human SAG Protein, C-Flag-tagged

• Cat.No.: SAG-567HFL
• Product Overview: Recombinant Full Length Human SAG Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 44.9 kDa
• AA Sequence: MAASGKTSKSEPNHVIFKKISRDKS VTIYLGNRDYIDHVSQVQPVDGVVL VDPDLVKGKKVYVTLTCAFR YGQEDIDVIGLTFRRDLYFSRVQVY PPVGAASTPTKLQESLLKKLGSNTY PFLLTFPDYLPCSVMLQPAP QDSGKSCGVDFEVKAFATDSTDAEE DKIPKKSSVRLLIRKVQHAPLEMGP QPRAEAAWQFFMSDKPLHLA VSLNKEIYFHGEPIPVTVTVTNNTE KTVKKIKAFVEQVANVVLYSSDYYV KPVAMEEAQEKVPPNSTLTK TLTLLPLLTNNRERRGIALDGKIKH EDTNLASSTIIKEGIDRTVLGILVS YQIKVKLTVSGFLGELTSSE
  VATEVPFRLMHPQPEDPAKESYQDA NLVFEEFARHNLKDAGEAEEGKRDK NDVDETRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: SAG S-antigen visual arrestin [ Homo sapiens (human) ]
• Official Symbol: SAG
• Synonyms: RP47; S-AG
• Gene ID: 6295
• mRNA Refseq: NM_000541.5
• Protein Refseq: NP_000532.2
• MIM: 181031
• UniProt ID: P10523