Recombinant Full Length Human SFPQ Protein, C-Flag-tagged

• Cat.No.: SFPQ-789HFL
• Product Overview: Recombinant Full Length Human SFPQ Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Enables DNA binding activity; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and regulation of transcription by RNA polymerase II. Acts upstream of or within double-strand break repair via homologous recombination. Located in chromatin; nuclear matrix; and paraspeckles.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 76.1 kDa
• AA Sequence: MSRDRFRSRGGGGGGFHRRGGGGGR GGLHDFRSPPPGMGLNQNRGPMGPG PGQSGPKPPIPPPPPHQQQQ QPPPQQPPPQQPPPHQPPPHPQPHQ QQQPPPPPQDSSKPVVAQGPGPAPG VGSAPPASSSAPPATPPTSG APPGSGPGPTPTPPPAVTSAPPGAP PPTPPSSGVPTTPPQAGGPPPPPAA VPGPGPGPKQGPGPGGPKGG KMPGGPKPGGGPGLSTPGGHPKPPH RGGGEPRGGRQHHPPYHQQHHQGPP PGGPGGRSEEKISDSEGFKA NLSLLRRPGEKTYTQRCRLFVGNLP ADITEDEFKRLFAKYGEPGEVFINK GKGFGFIKLESRALAEIAKA ELDDTPMRGRQLRVRFATHAAALSV RNLSPYVSNELLEEAFSQFGPIERA VVIVDDRGRSTGKGIVEFAS KPAARKAFERCSEGVFLLTTTPRPV IVEPLEQLDDEDGLPEKLAQKNPMY QKERETPPRFAQHGTFEYEY SQRWKSLDEMEKQQREQVEKNMKDA KDKLESEMEDAYHEHQANLLRQDLM RRQEELRRMEELHNQEMQKR KEMQLRQEEERRRREEEMMIRQREM EEQMRRQREESYSRMGYMDPRERDM RMGGGGAMNMGDPYGSGGQK FPPLGGGGGIGYEANPGVPPATMSG SMMGSDMRTERFGQGGAGPVGGQGP RGMGPGTPAGYGRGREEYEG
  PNKKPRFTRTRPLEQKLISEEDLAA NDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Transcription Factors

Gene Information

• Gene Name: SFPQ splicing factor proline and glutamine rich [ Homo sapiens (human) ]
• Official Symbol: SFPQ
• Synonyms: PSF; POMP100; PPP1R140
• Gene ID: 6421
• mRNA Refseq: NM_005066.3
• Protein Refseq: NP_005057.1
• MIM: 605199
• UniProt ID: P23246