Recombinant Full Length Rat Insulin-Like Growth Factor 1 Receptor(Igf1R) Protein, His-Tagged

• Cat.No.: RFL12998RF
• Product Overview: Recombinant Full Length Rat Insulin-like growth factor 1 receptor(Igf1r) Protein (P24062) (31-737aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Rattus norvegicus (Rat)
• Tag: His
• Form: Lyophilized powder
• Protein length: Full Length (31-737)
• AA Sequence: EICGPGIDIRNDYQQLKRLENCTVI EGFLHILLISKAEDYRSYRFPKLTV ITEYLLLFRVAGLESLGDLFPNLTV IRGWKLFYNYALVIFEMTNLKDIGL YNLRNITRGAIRIEKNADLCYLSTI DWSLILDAVSNNYIVGNKPPKECGD LCPGTLEEKPMCEKTTINNEYNYRC WTTNRCQKMCPSVCGKRACTENNEC CHPECLGSCHTPDDNTTCVACRHYY YKGVCVPACPPGTYRFEGWRCVDRD FCANIPNAESSDSDGFVIHDGECMQ ECPSGFIRNSTQSMYCIPCEGPCPK VCGDEEKKTKTIDSVTSAQMLQGCT ILKGNLLINIRRGNNIASELENFMG LIEVVTGYVKIRHSHALVSLSFLKN LRLILGEEQLEGNYSFYVLDNQNLQ QLWDWNHRNLTVRSGKMYFAFNPKL CVSEIYRMEEVTGTKGRQSKGDINT RNNGERASCESDVLRFTSTTTWKNR IIITWHRYRPPDYRDLISFTVYYKE APFKNVTEYDGQDACGSNSWNMVDV DLPPNKEGEPGILLHGLKPWTQYAV YVKAVTLTMVENDHIRGAKSEILYI RTNASVPSIPLDVLSASNSSSQLIV KWNPPTLPNGNLSYYIVRWQRQPQD GYLFRHNYCSKDKIPIRKYADGTID VEEVTENPKTEVCGGDKGPCCACPK TEAEKQAEKEEAEYRKVFENFLHNS IFVPRPERRRRDVLQVANTTMSSRS RNTTVADTYNIT
• Purity: Greater than 90% as determined by SDS-PAGE.
• Applications: SDS-PAGE
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: Igf1r
• Synonyms: Igf1r; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221
• UniProt ID: P24062

Gene Information

• Gene Name: Igf1r
• Synonyms: Igf1r; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221
• UniProt ID: P24062

Reviews

07/08/2022

The product's exceptional purity facilitated precise quantification, ensuring data consistency.

06/14/2019

The product consistently delivered robust and dependable results, affirming its efficacy in our experiments.

04/29/2018

The product's consistent performance bolstered the dependability of our research conclusions.

Q&As

In which cellular compartments is IGF1R predominantly localized?

IGF1R is predominantly localized on the cell membrane, where it acts as a receptor for insulin-like growth factors (IGFs) and insulin.

Are there specific downstream signaling pathways activated by IGF1R, and how do they influence cell proliferation and survival?

Downstream signaling pathways activated by IGF1R include the Ras/MAPK pathway and PI3K/Akt pathway, contributing to cell growth and survival.

How does IGF1R interact with insulin-like growth factors (IGFs) and insulin, and what is its role in growth regulation?

IGF1R interacts with IGFs and insulin, triggering downstream signaling pathways such as the PI3K/Akt pathway, influencing cell proliferation and survival.

Are there therapeutic implications or potential targets related to IGF1R in diseases involving growth signaling?

There are potential therapeutic implications related to IGF1R in diseases involving growth signaling, making it a target for drug development.

What diseases or conditions are associated with dysregulation or abnormal expression of IGF1R?

Dysregulation or abnormal expression of IGF1R is associated with conditions such as cancer and developmental disorders.

What is the primary function of Insulin-like growth factor 1 receptor (IGF1R) in cellular processes and growth signaling?

Insulin-like growth factor 1 receptor (IGF1R) functions in cellular processes, primarily playing a role in growth signaling.

How does IGF1R contribute to the regulation of tissue development, particularly in the context of growth and differentiation?

IGF1R contributes to the regulation of tissue development by influencing cell growth, differentiation, and survival.