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Recombinant Human ABCC8 Protein, GST-Tagged

Cat.No. : ABCC8-053H
Product Overview : Human ABCC8 partial ORF ( NP_000343, 611 a.a. - 710 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 36.74 kDa
AA Sequence : SEFLSSAEIREEQCAPHEPTPQGPA SKYQAVPLRVVNRKRPAREDCRGLT GPLQSLVPSADGDADNCCVQIMGGY FTWTPDGIPTLSNITIRIPRGQLTM
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 [ Homo sapiens ]
Official Symbol : ABCC8
Synonyms : ABCC8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; HRINS, SUR; ATP-binding cassette sub-family C member 8; ABC36; HHF1; HI; MRP8; PHHI; sulfonylurea receptor (hyperinsulinemia); SUR1; TNDM2; sulfonylurea receptor 1; ATP-binding cassette transporter sub-family C member 8; SUR; HRINS; SUR1delta2;
Gene ID : 6833
mRNA Refseq : NM_000352
Protein Refseq : NP_000343
MIM : 600509
UniProt ID : Q09428

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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