Recombinant Human ABCC8 Protein, MYC/DDK-tagged

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Recombinant Human ABCC8 Protein, MYC/DDK-tagged

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Cat.No. : ABCC8-238H
Product Overview : Recombinant human ABCC8 protein, fused to MYC/DDK-tag at C-terminal, was expressed in HEK293.
Description : The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013].
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 176.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : ATP binding cassette subfamily C member 8 [ Homo sapiens ]
Official Symbol : ABCC8
Synonyms : ABC36; HHF1; HI; HRINS; MRP8; PHHI; SUR; SUR1; SUR1delta2; TNDM2
Gene ID : 6833
mRNA Refseq : NM_000352.3
Protein Refseq : NP_000343.2
MIM : 600509
UniProt ID : Q09428

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