| Description : |
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
82.3 kDa |
| AA Sequence : |
MDALKPPCLWRNHERGKKDRDSCGR KNSEPGSPHSLEALRDAAPSQGLNF LLLFTKMLFIFNFLFSPLPTPALIC ILTFGAAIFLWLITRPQPVLPLLDL NNQSVGIEGGARKGVSQKNNDLTSC CFSDAKTMYEVFQRGLAVSDNGPCL GYRKPNQPYRWLSYKQVSDRAEYLG SCLLHKGYKSSPDQFVGIFAQNRPE WIISELACYTYSMVAVPLYDTLGPE AIVHIVNKADIAMVICDTPQKALVL IGNVEKGFTPSLKVIILMDPFDDDL KQRGEKSGIEILSLYDAENLGKEHF RKPVPPSPEDLSVICFTSGTTGDPK GAMITHQNIVSNAAAFLKCVEHAYE PTPDDVAISYLPLAHMFERIVQAVV YSCGARVGFFQGDIRLLADDMKTLK PTLFPAVPRLLNRIYDKVQNEAKTP LKKFLLKLAVSSKFKELQKGIIRHD SFWDKLIFAKIQDSLGGRVRVIVTG AAPMSTSVMTFFRAAMGCQVYEAYG QTECTGGCTFTLPGDWTSGHVGVPL ACNYVKLEDVADMNYFTVNNEGEVC IKGTNVFKGYLKDPEKTQEALDSDG WLHTGDIGRWLPNGTLKIIDRKKNI FKLAQGEYIAPEKIENIYNRSQPVL QIFVHGESLRSSLVGVVVPDTDVLP SFAAKLGVKGSFEELCQNQVVREAI LEDLQKIGKESGLKTFEQVKAIFLH PEPFSIENGLLTPTLKAKRGELSKY FRTQIDSLYEHIQDTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
