Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Recombinant Human ADAMTS5 Protein, His-tagged

Cat.No. : ADAMTS5-306H
Product Overview : Human ADAMTS5 amino acids 625-930 deleted recombinant protein with His tag expressed in insect cells.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]
Source : Insect Cell
Species : Human
Tag : His
Form : Liquid
Bio-activity : >= 5 mU/mg
Molecular Mass : 40.8 kDa
Purity : >= 50% by SDS-PAGE
Applications : Functional Study
SDS-PAGE
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Concentration : 0.1 mg/mL
Storage Buffer : In 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, pH 7.5 (50 mM imidazol, 0.05% Brij-35 detergent)
Gene Name : ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 [ Homo sapiens ]
Official Symbol : ADAMTS5
Synonyms : ADAMTS5; ADAM metallopeptidase with thrombospondin type 1 motif, 5; a disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase 2); A disintegrin and metalloproteinase with thrombospondin motifs 5; ADAMTS11; ADMP 2; aggrecanase 2; aggrecanase-2; a disintegrin and metalloproteinase with thrombospondin motifs 11; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2); ADMP-2; ADAM-TS5; ADAMTS-5; ADAM-TS 5; ADAMTS-11; ADAM-TS 11;
Gene ID : 11096
mRNA Refseq : NM_007038
Protein Refseq : NP_008969
MIM : 605007
UniProt ID : Q9UNA0

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Do you offer ADAMTS5 fused with other tags? 07/16/2022

We can provide you with the most suitable labels according to your experimental needs.

ADAMTS5 is used in studies of which diseases? 06/09/2021

ADAMTS5 is used in the study of oral squamous cell carcinoma, gastric cancer, and many other cancers.

How does ADAMTS5 relate to Aggrecan? 01/09/2021

ADAMTS5 can cut Aggrecan.

What is the structure domain of ADAMTS5? 01/05/2021

DAMTS5 is composed of a signal peptide, a pro-domain, a catalytic metalloproteinase domain, a disintegrin-like domain, and other C-terminal ancillary domains (a central thrombospondin type 1 sequence repeat (central TSR) motif, a cysteine-rich domain, a spacer region, and an additional TSR motif).

What biological processes is ADAMTS5 involved in? 07/03/2020

ADAMTS5 is involved in the degradation of polyproteoglycans.

Customer Reviews (3)

Write a review
Reviews
06/24/2020

    The staff was very nice, communicated with me positively and solved a lot of technical problems.

    06/19/2020

      The ADAMTS5 proteins purchased from your company is suitable for ELISA.

      06/17/2020

        Fast and timely shipment helped me to get satisfactory experimental results in short time.

        Ask a Question for All ADAMTS5 Products

        Required fields are marked with *

        My Review for All ADAMTS5 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends