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Active Recombinant Human AHSG Protein

Cat.No. : AHSG-469H
Product Overview : Human AHSG (P02765) partial recombinant protein expressed in HEK293 cells.
  • Specification
  • Gene Information
  • Related Products
Description : Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]
Source : HEK293 cell
Species : Human
Form : Lyophilized
Bio-activity : Determined by its ability to inhibit Cathespin V cleavage of a fluorogenic peptide substrate Z-LR-AMC (RLUs). The expected IC50 is ≤ 100nM.
Molecular Mass : 45-55 kDa
AA Sequence : A-Chain:APHGPGLIYRQPNCDDPETEEAALV AIDYINQNLPWGYKHTLNQIDEVKV WPQQPSGELFEIEIDTLETTCHVLD PTPVARCSVRQLKEHAVEGDCDFQL LKLDGKFSVVYAKCDSSPDSAEDVR KVCQDCPLLAPLNDTRVVHAAKAAL AAFNAQNNGSNFQLEEISRAQLVPL PPSTYVEFTVSGTDCVAKEATEAAK CNLLAEKQYGFCKATLSEKLGGAEV AVTCTVFQTQPVTSQPQPEGANEAV PTPVVDPDAPPSPPLGAPGLPPAGS PPDSHVLB-Chain:TVVQPSVGAAAGPVVPPCPGRIRHF KV
Endotoxin : Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug).
Purity : 98%
Applications : Functional Study
SDS-PAGE
Usage : Activity assay
SDS-PAGE
The optimal working dilution should be determined by the end user.
Storage : Store at -20centigrade.Aliquot to avoid repeated freezing and thawing.
Storage Buffer : Lyophilized from solutions contain no sodiun azide nor carrier protein
Gene Name : AHSG alpha-2-HS-glycoprotein [ Homo sapiens ]
Official Symbol : AHSG
Synonyms : AHSG; alpha-2-HS-glycoprotein; A2HS; FETUA; HSGA; fetuin-A; alpha-2-Z-globulin; ba-alpha-2-glycoprotein; AHS;
Gene ID : 197
mRNA Refseq : NM_001622
Protein Refseq : NP_001613
MIM : 138680
UniProt ID : P02765

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

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Q&As (10)

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How can proteomics approaches be used to study the protein-protein interactions involving AHSG in a global context? 08/14/2022

Techniques like co-immunoprecipitation coupled with mass spectrometry can reveal AHSG's interactome, shedding light on its broader functional networks.

Explain the potential diagnostic applications of AHSG in conditions such as chronic kidney disease and diabetes? 07/09/2022

AHSG levels may be altered in these conditions, making it a potential biomarker for disease progression or severity.

Explain the potential role of AHSG in mediating endocrine functions and its connection to insulin resistance? 12/31/2021

AHSG's interaction with insulin and adipokines could impact insulin sensitivity and metabolism, contributing to insulin resistance in conditions like type 2 diabetes.

Discuss the interactions between AHSG and other proteins, particularly its relationship with fetuin-B and fetuin-A? 06/11/2021

AHSG can form complexes with fetuin-B and fetuin-A, which have implications for calcium homeostasis, insulin signaling, and other physiological processes.

Explain AHSG's role in modulating immune responses and its potential relevance to autoimmune disorders? 08/02/2020

AHSG can interact with immune cells and cytokines, potentially influencing immune responses. Dysregulated AHSG levels might contribute to autoimmune diseases.

How might AHSG's interactions with circulating proteins influence its functions and its potential clinical relevance? 02/19/2020

AHSG's interactions with proteins like albumin and hormones can impact its bioavailability and activity, influencing physiological processes.

Describe the biochemical methods used to analyze AHSG's post-translational modifications, including glycosylation. 06/13/2019

Techniques such as mass spectrometry, lectin affinity chromatography, and glycan analysis can provide insights into AHSG's glycosylation patterns.

How does AHSG regulate calcium homeostasis, and what implications does this have for human health? 03/22/2019

AHSG binds to calcium ions and influences their distribution in the body. Dysregulation may impact bone health and contribute to conditions like osteoporosis.

How can researchers isolate and purify AHSG for biochemical studies in the laboratory? 10/28/2018

Techniques such as ion exchange chromatography, gel filtration, and affinity chromatography can be used to isolate and purify AHSG from biological samples.

How might genetic variations in the AHSG gene impact its protein expression and functions? 05/04/2018

Genetic polymorphisms in the AHSG gene might lead to altered AHSG levels or structural changes, potentially influencing its physiological roles.

Customer Reviews (5)

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Reviews
06/03/2022

    Absolutely loving the lab protein – a real game changer!

    10/19/2021

      Great value for the quality, and the speedy delivery was a pleasant surprise!

      08/16/2020

        Thumbs up for the protein, it's become my new favorite.

        02/27/2019

          Can't help but smile at the results from the product!

          12/11/2018

            Balanced pricing, superior quality, and top-level customer assistance.

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