Recombinant Human ALK protein, His-tagged
Cat.No. : | ALK-2573H |
Product Overview : | Recombinant Human ALK protein(43-366 aa), fused to His tag, was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 300mM imidazole. |
Protein length : | 43-366 aa |
AA Sequence : | PLSYSRLQRKSLAVDFVVPSLFRVY ARDLLLPPSSSELKAGRPEARGSLA LDCAPLLRLLGPAPGVSWTAGSPAP AEARTLSRVLKGGSVRKLRRAKQLV LELGEEAILEGCVGPPGEAAVGLLQ FNLSELFSWWIRQGEGRLRIRLMPE KKASEVGREGRLSAAIRASQPRLLF QIFGTGHSSLESPTNMPSPSPDYFT WNLTWIMKDSFPFLSHRSRYGLECS FDFPCELEYSPPLHDLRNQSWSWRR IPSEEASQMDLLDGPGAERSKEMPR GSFLLLNTSADSKHTILSPWMRSSS EHCTLAVSVHRHLQPSGRYIAQLL |
Purity : | 95%, by SDS-PAGE with Coomassie Brilliant Blue staining. |
Storage : | Short-term storage: Store at 2-8°C for (1-2 weeks). Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles. |
Reconstitution : | Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage. Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage. |
Gene Name : | ALK anaplastic lymphoma receptor tyrosine kinase [ Homo sapiens ] |
Official Symbol : | ALK |
Synonyms : | ALK; anaplastic lymphoma receptor tyrosine kinase; anaplastic lymphoma kinase (Ki 1); ALK tyrosine kinase receptor; CD246; CD246 antigen; mutant anaplastic lymphoma kinase; NBLST3; |
Gene ID : | 238 |
mRNA Refseq : | NM_004304 |
Protein Refseq : | NP_004295 |
MIM : | 105590 |
UniProt ID : | Q9UM73 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (17)
Ask a questionThe common mutation of ALK and other genes may affect the prognosis and therapeutic effect of lung cancer, and provide new ideas for individualized treatment.
Phosphorylation of ALK can affect its activity and signal transmission efficiency, which has an impact on the biological process of cells.
The application prospect of ALK in the treatment of breast cancer needs to be further studied and discussed, and the expression level in breast cancer cells is not clear.
The interaction between ALK and other tumor suppressor genes may affect the occurrence and development of tumors, and provide new ideas for tumor treatment.
This is involved in a variety of lung cancer signaling pathways, such as PI3K/Akt, MAPK/ERK, STAT3 and other pathways.
It is associated with lung cancer, thyroid cancer, lymphoma and neuroblastoma.
As a targeted drug, ALK is mainly used by oral administration and intravenous injection, which can help in the treatment of diseases such as lung cancer.
ALK is overexpressed in a small number of lung cancer patients and is involved in the occurrence and development of lung cancer.
The mutation may affect the prognosis and therapeutic effect of lung cancer, suggesting the importance of ALK targeted therapy.
ALK is involved in signal transduction and cell growth in nervous system tumors, and has a certain influence on the occurrence and development of nervous system tumors.
ALK plays an important role in many physiological processes such as neuron migration, embryonic development and osteoblast differentiation.
ALK can be used as one of the screening indicators for lung cancer, which can help the early diagnosis and treatment of lung cancer.
ALK is expressed in a variety of cell types such as the nervous system, lymphatic system, and immune system, and is involved in a variety of biological processes.
The regulatory mechanisms of ALK mainly include gene mutation, gene expression regulation, quality control and signal pathway regulation.
The effect of ALK targeted therapy on the prognosis of lung cancer may be related to a variety of factors, including tumor stage, pathological type, treatment regimen, etc.
ALK can be used as an important marker of targeted therapy in the treatment of lung cancer, providing an individualized treatment strategy.
The relationship between ALK and colorectal cancer is unclear and needs further study.
Customer Reviews (4)
Write a reviewALK has strict quality control and complies with relevant industry standards.
The yield of ALK is high and has good economic benefits.
The enzymatic activity of ALK reached the expected level and was able to play a role in specific reactions.
Stable and reproducible results can be obtained when experiments are performed using ALK.
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