Recombinant Human ALOX12 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | ALOX12-2197H |
Product Overview : | ALOX12 MS Standard C13 and N15-labeled recombinant protein (NP_000688) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 75.5 kDa |
AA Sequence : | MGRYRIRVATGAWLFSGSYNRVQLW LVGTRGEAELELQLRPARGEEEEFD HDVAEDLGLLQFVRLRKHHWLVDDA WFCDRITVQGPGACAEVAFPCYRWV QGEDILSLPEGTARLPGDNALDMFQ KHREKELKDRQQIYCWATWKEGLPL TIAADRKDDLPPNMRFHEEKRLDFE WTLKAGALEMALKRVYTLLSSWNCL EDFDQIFWGQKSALAEKVRQCWQDD ELFSYQFLNGANPMLLRRSTSLPSR LVLPSGMEELRAQLEKELQNGSLFE ADFILLDGIPANVIRGEKQYLAAPL VMLKMEPNGKLQPMVIQIQPPNPSS PTPTLFLPSDPPLAWLLAKSWVRNS DFQLHEIQYHLLNTHLVAEVIAVAT MRCLPGLHPIFKFLIPHIRYTMEIN TRARTQLISDGGIFDKAVSTGGGGH VQLLRRAAAQLTYCSLCPPDDLADR GLLGLPGALYAHDALRLWEIIARYV EGIVHLFYQRDDIVKGDPELQAWCR EITEVGLCQAQDRGFPVSFQSQSQL CHFLTMCVFTCTAQHAAINQGQLDW YAWVPNAPCTMRMPPPTTKEDVTMA TVMGSLPDVRQACLQMAISWHLSRR QPDMVPLGHHKEKYFSGPKPKAVLN QFRTDLEKLEKEITARNEQLDWPYE YLKPSCIENSVTISGPTRTRRLEQK LISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | ALOX12 arachidonate 12-lipoxygenase [ Homo sapiens (human) ] |
Official Symbol : | ALOX12 |
Synonyms : | ALOX12; arachidonate 12-lipoxygenase; arachidonate 12-lipoxygenase, 12S-type; 12S LOX; platelet 12 LOX; platelet 12-LOX; 12S-lipoxygenase; 12(S)-lipoxygenase; platelet-type 12-lipoxygenase; platelet-type lipoxygenase 12; LOG12; 12-LOX; 12S-LOX; |
Gene ID : | 239 |
mRNA Refseq : | NM_000697 |
Protein Refseq : | NP_000688 |
MIM : | 152391 |
UniProt ID : | P18054 |
Products Types
◆ Recombinant Protein | ||
ALOX12-01H | Recombinant Human ALOX12 Protein | +Inquiry |
ALOX12-323H | Recombinant Human ALOX12 Protein, His (Fc)-Avi-tagged | +Inquiry |
Alox12-578M | Recombinant Mouse Alox12 Protein, MYC/DDK-tagged | +Inquiry |
Alox12-104M | Recombinant Mouse Alox12 Protein, His-tagged | +Inquiry |
Alox12-021M | Recombinant mouse Alox12 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ALOX12-64HCL | Recombinant Human ALOX12 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (13)
Ask a questionIt is involved in the pathological process of virus-induced hepatitis, which may be related to virus clearance and liver disease recovery.
This is associated with some signaling pathways, such as PI3K/AKT pathway and MAPK pathway.
ALOX12 is involved in several biological processes associated with obesity, such as adipocyte differentiation, glucose and lipid metabolism.
ALOX12 is involved in the occurrence and development of a variety of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease.
ALOX12 is involved in endothelial cell function impairment and is associated with diabetic complications.
This is a membrane binding protein with a core membrane binding domain and an extramembrane catalytic domain.
The oxidizes linolenic acid to produce 12S-LOX and 15S-LOX metabolites by oxygenation.
This protein is mainly involved in the metabolic pathway of linolenic acid, catalyzing the synthesis of 12S-LOX and 15S-LOX metabolites.
ALOX12 catalyzes linolenic acid to produce 12S-LOX and 15S-LOX metabolites, which have biological activities, including participating in inflammatory responses, regulating platelet activation, and regulating T cell function.
It is expressed in a variety of tissues in the human body, such as the skin, heart, lungs, liver, kidneys, intestines, and nervous system.
The human ALOX12 gene has a variety of variants, including SNP and InDel, that can lead to its dysfunction or increased risk.
ALOX12 is involved in the process of myocardial cell damage after myocardial infarction, which may be related to myocardial regeneration and repair.
ALOX12 is believed to be associated with a variety of diseases, such as cancer, inflammation, neurodegenerative diseases, cardiovascular disease, and more.
Customer Reviews (4)
Write a reviewIt has good efficacy and high safety as an immunotherapy drug.
ALOX12 has a good inhibitory effect on cell proliferation and survival.
There is no interaction or influence with other drugs.
Functionally enhanced or altered by protein modification techniques.
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