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Recombinant Human ALOX12 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : ALOX12-2197H
Product Overview : ALOX12 MS Standard C13 and N15-labeled recombinant protein (NP_000688) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 75.5 kDa
AA Sequence : MGRYRIRVATGAWLFSGSYNRVQLW LVGTRGEAELELQLRPARGEEEEFD HDVAEDLGLLQFVRLRKHHWLVDDA WFCDRITVQGPGACAEVAFPCYRWV QGEDILSLPEGTARLPGDNALDMFQ KHREKELKDRQQIYCWATWKEGLPL TIAADRKDDLPPNMRFHEEKRLDFE WTLKAGALEMALKRVYTLLSSWNCL EDFDQIFWGQKSALAEKVRQCWQDD ELFSYQFLNGANPMLLRRSTSLPSR LVLPSGMEELRAQLEKELQNGSLFE ADFILLDGIPANVIRGEKQYLAAPL VMLKMEPNGKLQPMVIQIQPPNPSS PTPTLFLPSDPPLAWLLAKSWVRNS DFQLHEIQYHLLNTHLVAEVIAVAT MRCLPGLHPIFKFLIPHIRYTMEIN TRARTQLISDGGIFDKAVSTGGGGH VQLLRRAAAQLTYCSLCPPDDLADR GLLGLPGALYAHDALRLWEIIARYV EGIVHLFYQRDDIVKGDPELQAWCR EITEVGLCQAQDRGFPVSFQSQSQL CHFLTMCVFTCTAQHAAINQGQLDW YAWVPNAPCTMRMPPPTTKEDVTMA TVMGSLPDVRQACLQMAISWHLSRR QPDMVPLGHHKEKYFSGPKPKAVLN QFRTDLEKLEKEITARNEQLDWPYE YLKPSCIENSVTISGPTRTRRLEQK LISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : ALOX12 arachidonate 12-lipoxygenase [ Homo sapiens (human) ]
Official Symbol : ALOX12
Synonyms : ALOX12; arachidonate 12-lipoxygenase; arachidonate 12-lipoxygenase, 12S-type; 12S LOX; platelet 12 LOX; platelet 12-LOX; 12S-lipoxygenase; 12(S)-lipoxygenase; platelet-type 12-lipoxygenase; platelet-type lipoxygenase 12; LOG12; 12-LOX; 12S-LOX;
Gene ID : 239
mRNA Refseq : NM_000697
Protein Refseq : NP_000688
MIM : 152391
UniProt ID : P18054

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (13)

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What role does ALOX12 play in hepatitis? 12/27/2022

It is involved in the pathological process of virus-induced hepatitis, which may be related to virus clearance and liver disease recovery.

What signaling pathways are involved in ALOX12? 08/22/2022

This is associated with some signaling pathways, such as PI3K/AKT pathway and MAPK pathway.

How does ALOX12 play in obesity? 07/31/2022

ALOX12 is involved in several biological processes associated with obesity, such as adipocyte differentiation, glucose and lipid metabolism.

How does ALOX12 play in neurodegenerative diseases? 12/10/2021

ALOX12 is involved in the occurrence and development of a variety of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease.

What role does ALOX12 play in diabetes? 11/24/2021

ALOX12 is involved in endothelial cell function impairment and is associated with diabetic complications.

What is the protein structure of ALOX12? 11/19/2021

This is a membrane binding protein with a core membrane binding domain and an extramembrane catalytic domain.

What is the catalytic mechanism of ALOX12? 04/07/2021

The oxidizes linolenic acid to produce 12S-LOX and 15S-LOX metabolites by oxygenation.

In what metabolic pathways does ALOX12 play a role? 12/08/2020

This protein is mainly involved in the metabolic pathway of linolenic acid, catalyzing the synthesis of 12S-LOX and 15S-LOX metabolites.

What role does ALOX12 play in cells? 07/23/2020

ALOX12 catalyzes linolenic acid to produce 12S-LOX and 15S-LOX metabolites, which have biological activities, including participating in inflammatory responses, regulating platelet activation, and regulating T cell function.

In which tissues is ALOX12 expressed? 07/15/2020

It is expressed in a variety of tissues in the human body, such as the skin, heart, lungs, liver, kidneys, intestines, and nervous system.

What are the variants of the ALOX12 gene? 05/30/2020

The human ALOX12 gene has a variety of variants, including SNP and InDel, that can lead to its dysfunction or increased risk.

Which role of ALOX12 in myocardial infarction? 03/26/2020

ALOX12 is involved in the process of myocardial cell damage after myocardial infarction, which may be related to myocardial regeneration and repair.

What diseases is ALOX12 associated with? 02/16/2020

ALOX12 is believed to be associated with a variety of diseases, such as cancer, inflammation, neurodegenerative diseases, cardiovascular disease, and more.

Customer Reviews (4)

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Reviews
11/03/2021

    It has good efficacy and high safety as an immunotherapy drug.

    03/31/2020

      ALOX12 has a good inhibitory effect on cell proliferation and survival.

      09/14/2019

        There is no interaction or influence with other drugs.

        01/27/2019

          Functionally enhanced or altered by protein modification techniques.

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