Recombinant Human Androgen Receptor Protein, His-tagged


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Recombinant Human Androgen Receptor Protein, His-tagged

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Cat.No. : AR-333H
Product Overview : Recombinant Human Androgen Receptor Protein is produced by Baculovirus expression system. This protein is fused with a His tag.
Description : AR (dihydrotestosterone receptor); testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease. The androgen receptor is an androgen-activated member of the nuclear receptor superfamily of transcription factors. Singnaling by the androgen receptor plays a key role in proper development and function of male reproductive organs. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein function as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. The androgen receptor (AR) has been shown to play a critical role in the development and progression of the prosate cancer.
Source : Insect cells
Species : Human
Tag : His
Form : 1x dilution buffer A: 20 mM Tris-HCl (pH 8.0), 20% Glycerol, 100 mM DTT and 0.2 mM EDTA.
Molecular Mass : 101 kDa
Purity : > 95% homogeneous based on SDS-PAGE analysis.
Unit Definition : 1 unit equals 1 nanogram of purified protein.
Applications : AR can be used for gel mobility shift assay, for protein-protein and small molecules-protein interactions assay.
Notes : For Research Use only.
Storage : Stored at -80 centigrade.
Concentration : 0.3 mg/ml (in 1x dilution buffer A)
Gene Name : AR androgen receptor [ Homo sapiens ]
Official Symbol : AR
Synonyms : AR; androgen receptor; AIS; HUMARA; Kennedy disease; NR3C4; SMAX1; KD; TFM; DHTR; SBMA; HYSP1;
Gene ID : 367
mRNA Refseq : NM_000044
Protein Refseq : NP_000035
MIM : 313700
UniProt ID : P10275
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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