Recombinant Human ANXA2R protein, GST-tagged

Cat.No. : ANXA2R-632H
Product Overview : Human ANXA2R full-length ORF ( NP_001014301.1, 1 a.a. - 193 a.a.) recombinant protein with GST-tag at N-terminal.
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Description : ANXA2R (Annexin A2 Receptor) is a Protein Coding gene.
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 48.1 kDa
AA Sequence : MEQHFLGCVKRAWDSAEVAPEPQPP PIVSSEDRGPWPLPLYPVLGEYSLD SCDLGLLSSPCWRLPGVYWQNGLSP GVQSTLEPSTAKPTEFSWPGTQKQQ EAPVEEVGQAEEPDRLRLQQLPWSS PLHPWDRQQDTEVCDSGCLLERRHP PALQPWRHLPGFSDCLEWILRVGFA AFSVLWACCSRICGAKQP
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
SDS-PAGE: 12.5% SDS-PAGE Stained with Coomassie Blue.
Gene Name : ANXA2R annexin A2 receptor [ Homo sapiens (human) ]
Official Symbol : ANXA2R
Synonyms : ANXA2R; annexin A2 receptor; AX2R; AXIIR; C5orf39; annexin-2 receptor; annexin II receptor
Gene ID : 389289
mRNA Refseq : NM_001014279
Protein Refseq : NP_001014301
MIM : 611296
UniProt ID : Q3ZCQ2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Are there any diseases associated with ANXA2R? 04/07/2021

ANXA2R has been implicated in cancer progression and metastasis. It is highly expressed in several cancer types, and its overexpression has been associated with poor prognosis. ANXA2R has also been suggested to play a role in autoimmune diseases and pathogen infection, although more research is needed to establish these associations.

Are there any therapeutic implications for targeting ANXA2R? 11/22/2020

Targeting ANXA2R has shown potential for therapeutic purposes. In cancer, blocking ANXA2R or its interaction with Annexin A2 may inhibit tumor invasion and metastasis. This could be achieved through the development of small molecule inhibitors, antibodies, or peptides that disrupt ANXA2R function. Additionally, modulating ANXA2R activity might be useful in cardiovascular diseases and autoimmune disorders, although more research is needed to identify specific therapeutic strategies.

Can ANXA2R interact with other proteins? 08/21/2020

Yes, ANXA2R can interact with a variety of proteins. One of its well-known interactions is with Annexin A2, forming a receptor-ligand complex. It can also interact with other cell adhesion molecules, signaling proteins, and cytoskeletal proteins, contributing to its diverse functions.

Can ANXA2R be used as a diagnostic or prognostic marker? 07/28/2020

ANXA2R has shown promise as a diagnostic and prognostic marker in certain cancers. Its overexpression has been associated with poor prognosis in breast cancer, colorectal cancer, and ovarian cancer. However, further studies are needed to validate its utility as a clinical marker in different diseases.

How is ANXA2R expressed in different tissues? 05/15/2020

ANXA2R is expressed in various tissues and cell types. It has been detected in the endothelium, epithelium, smooth muscle cells, and neurons. Its expression levels can vary depending on the tissue type and physiological context.

How is ANXA2R implicated in cancer? 05/03/2020

ANXA2R has been implicated in cancer through its involvement in processes such as cell migration, invasion, and metastasis. Its overexpression has been observed in various types of cancer and is often associated with poor prognosis. ANXA2R can promote tumor cell invasion by interacting with Annexin A2 and other proteins involved in cell adhesion and cytoskeletal rearrangement. Furthermore, ANXA2R can modulate signaling pathways that contribute to tumor growth and survival.

Are there any ongoing research studies related to ANXA2R? 12/10/2019

Yes, there are ongoing research studies investigating various aspects of ANXA2R. Some studies aim to elucidate the precise role of ANXA2R in cancer progression, as well as its potential as a therapeutic target. Other studies focus on understanding ANXA2R's involvement in cardiovascular diseases, autoimmune disorders, and other pathological conditions. Additionally, continuing research aims to identify novel molecular mechanisms and signaling pathways associated with ANXA2R.

How is ANXA2R related to Annexin A2? 12/02/2019

ANXA2R is the receptor for Annexin A2. Annexin A2 is a calcium-dependent phospholipid-binding protein that interacts with ANXA2R to form a receptor-ligand complex. This complex is involved in various cellular functions, including the regulation of cell adhesion and membrane trafficking.

How is ANXA2R regulated? 05/10/2018

ANXA2R expression and activity can be regulated at multiple levels. Transcriptional regulation by various transcription factors can influence ANXA2R expression. Post-translational modifications, such as phosphorylation and glycosylation, can modulate its function and localization. Furthermore, signaling pathways, growth factors, and cytokines can regulate ANXA2R activity, affecting its interactions with other proteins and downstream signaling events.

Is ANXA2R involved in any other diseases or conditions? 07/20/2017

Apart from cancer, ANXA2R has been implicated in several other diseases and conditions. It has been associated with cardiovascular diseases, such as atherosclerosis and cardiac fibrosis, playing a role in vascular remodeling, endothelial dysfunction, and inflammation. ANXA2R has also been linked to autoimmune disorders like rheumatoid arthritis and systemic lupus erythematosus, potentially contributing to immune dysregulation and tissue damage.

Customer Reviews (4)

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Reviews
05/30/2021

    Highly recommended and known for its outstanding performance in ELISA, the ANXA2R protein is a top choice for researchers in protein electron microscopy structure analysis.

    02/09/2021

      Its versatility and reliability make it a great asset in the pursuit of scientific discoveries.

      05/22/2018

        Its exceptional properties and reliable results make it a valuable tool in various experimental applications.

        07/12/2017

          With the ANXA2R protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.

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