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Active Recombinant Human AOC3 protein

Cat.No. : AOC3-9402H
Product Overview : Recombinant Human AOC3(27-763 aa) was expressed in CHO.
  • Specification
  • Gene Information
  • Related Products
Description : Vascular adhesion protein­1 (VAP­1) is a type II membrane cell adhesion protein belonging to the copper/topaquinone oxidase family and functions both as an enzyme and an adhesion molecule for lymphocytes. VAP-1 is primarily expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Inhibition of VAP-1 can protect against inflammation related damage to certain injured tissues.
Source : CHO
Species : Human
Bio-activity : Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity > 16 pMoles/min/µg of VAP-1.
Molecular Mass : Recombinant VAP-1 is a mixture of monomeric and disulfide linked homodimeric forms of a 737 amino acid polypeptide corresponding to amino acids 27 to 763 of the VAP-1 precursor.
AA Sequence : GRGGDGGEPS QLPHCPSVSP SAQPWTHPGQ SQLFADLSRE ELTAVMRFLT QRLGPGLVDA AQARPSDNCV FSVELQLPPKAAALAHLDRG SPPPAREALA IVFFGRQPQP NVSELVVGPL PHPSYMRDVT VERHGGPLPY HRRPVLFQEY LDIDQMIFNRELPQASGLLH HCCFYKHRGR NLVTMTTAPR GLQSGDRATW FGLYYNISGA GFFLHHVGLE LLVNHKALDP ARWTIQKVFY
QGRYYDSLAQ LEAQFEAGLV NVVLIPDNGT GGSWSLKSPV PPGPAPPLQF YPQGPRFSVQ GSRVASSLWT FSFGLGAFSGPRIFDVRFQG ERLVYEISLQ EALAIYGGNS PAAMTTRYVD GGFGMGKYTT PLTRGVDCPY LATYVDWHFL LESQAPKTIRDAFCVFEQNQ GLPLRRHHSD LYSHYFGGLA ETVLVVRSMS TLLNYDYVWD TVFHPSGAIE IRFYATGYIS SAFLFGATGK
YGNQVSEHTL GTVHTHSAHF KVDLDVAGLE NWVWAEDMVF VPMAVPWSPE HQLQRLQVTR KLLEMEEQAA FLVGSATPRYLYLASNHSNK WGHPRGYRIQ MLSFAGEPLP QNSSMARGFS WERYQLAVTQ RKEEEPSSSS VFNQNDPWAP TVDFSDFINNETIAGKDLVA WVTAGFLHIP HAEDIPNTVT VGNGVGFFLR PYNFFDEDPS FYSADSIYFR GDQDAGACEV NPLACLPQAA
ACAPDLPAFS HGGFSHN
Endotoxin : Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Purity : 98%
Applications : Bioassay
Storage : Store product at -20 centigrade.
Gene Name : AOC3 amine oxidase, copper containing 3 (vascular adhesion protein 1) [ Homo sapiens ]
Official Symbol : AOC3
Synonyms : AOC3; amine oxidase, copper containing 3 (vascular adhesion protein 1); membrane primary amine oxidase; HPAO; VAP 1; VAP1; copper amine oxidase; vascular adhesion protein 1; semicarbazide-sensitive amine oxidase; SSAO; VAP-1;
Gene ID : 8639
mRNA Refseq : NM_003734
Protein Refseq : NP_003725
MIM : 603735
UniProt ID : Q16853

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (18)

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Is AOC3 suitable for children? 12/21/2022

There is no clear data on the use of AOC3 in children, and more research is needed to determine its safety and efficacy.

What is AOC3 used for? 11/10/2022

AOC3 is an important enzyme that produces human myocardial peptides, which play a key role in heart function and blood pressure regulation.

Have there been relevant studies showing that AOC3 can improve cardiac function? 08/27/2022

Some studies have shown that AOC3 may have a certain improvement in cardiac function, but more clinical trials are needed to verify it.

What are the potential side effects of AOC3 therapy? 09/07/2021

It has not been fully determined, but some possible adverse effects include allergic reactions, digestive discomfort and headaches.

Is AOC3 suitable for all patients with cardiovascular disease? 08/09/2021

There is no clear data showing that AOC3 is suitable for all patients with cardiovascular disease, and the specific application scope needs further research.

Is the combination of AOC3 with other cardiovascular drugs safe? 08/02/2021

There is no clear data showing adverse interactions between AOC3 and other cardiovascular drugs, but it should be used in accordance with doctor's recommendations.

How to treat AOC3 ? 07/03/2021

At present, AOC3 therapy is mainly administered by injection.

Can AOC3 be used in the treatment of angina? 04/30/2021

AOC3 has certain potential for the treatment of angina pectoris, but the specific effect needs to be further verified.

Is there any research to explore the application of AOC3 in the treatment of pulmonary hypertension? 02/21/2021

Yes, some studies have explored the potential of AOC3 in the treatment of pulmonary hypertension, but more research is needed to determine its clinical effect.

How to determine the dose of AOC3 ? 01/08/2021

The determination of dosage is usually based on specific study design and treatment goals, and multi-center, large-sample studies are required to determine the optimal dose in clinical practice.

What is the progress of clinical trials on AOC3 ? 11/27/2020

Clinical trials of AOC3 are ongoing to evaluate its safety and efficacy in the treatment of different diseases.

How does AOC3 regulate blood pressure? 10/04/2020

AOC3 can reduce arterial blood pressure and reduce angiotensin II activity through degradation.

Does AOC3 have potential applications in rehabilitation after myocardial infarction? 09/01/2020

There is some evidence that AOC3 may have a certain application prospect in the rehabilitation process after myocardial infarction, but more research is needed to verify its clinical effect.

How long does the therapeutic effect of AOC3 last? 08/03/2020

Studies used in the treatment of pulmonary hypertension have shown that the therapeutic effect of AOC3 diminishes over time.

Is there any scientific research on the association between AOC3 and heart disease? 05/24/2020

There have been academic studies showing an association between AOC3 and heart disease, and it is involved in angiotensin production, left ventricular hypertrophy and angina pectoris.

How to evaluate the clinical efficacy of AOC3 ? 01/31/2020

The clinical efficacy of AOC3 is usually evaluated through multicenter, randomized controlled clinical trials.

Does AOC3 have clinical application? 01/27/2020

Yes, AOC3 has the potential to be used in the clinic to treat cardiovascular disease and related diseases such as hypertension.

Are there any AOC3 drugs on the market? 06/14/2019

There are currently no commercially available AOC3 drugs, but clinical trials are ongoing.

Customer Reviews (4)

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Reviews
07/16/2022

    I appreciate the Aoc3 manufacturer's attention to product quality, and their product repeatability is very good, which makes our experiment more smooth.

    12/11/2021

      Aoc3 can be stored at room temperature for several days without deterioration, which allows us to easily conduct experiments and obtain reliable results.

      05/25/2021

        Purity is very high, showing good production process and quality control.

        04/11/2020

          Solubility of Aoc3 demonstrated well in Western blots and can be easily dissolved in a variety of buffers.

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