Recombinant Human AP5Z1 protein, GST-tagged

• Cat.No.: AP5Z1-664H
• Product Overview: Human AP5Z1 full-length ORF ( AAH37399, 1 a.a. - 446 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). [provided by RefSeq, Jan 2011]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 74.8 kDa
• AA Sequence: MAKVVVLSPGTLQEDQATLLSKRLV DWLRYASLQQGLPHSGGFFSTPRAR QPGPVTEVDGAVATDFFTVLSSGHR FTDDQWLNVQAFSMLRAWLLHSGPE GPGTLDTDDRSEQEGSTLSVISATS SAGRLLPPRERLREVAFEYCQRLIE QSNRRALRKGDSDLQKACLVEAVLV LDVLCRQDPSFLYRSLSCLKALHGR VRGDPASVRVLLPLAHFFLSHGEAA AVDSEAVYQHLFTRIPVEQFHSPML AFEFIQFCRDNLHLFSGHLSTLRLS FPNLFKFLAWNSPPLTSEFVALLPA LVDAGTALEMLHALLDLPCLTAVLD LQLRSAPAASERPLWDTSLRAPSCL EAFRDPQFQGLFQYLLRPKASGATE RLAPLHQLLQPMAGCARVAQCAQAV PTLLQAFFSAVTQVADGSLINQLAL LLLGRSDSLYPAPGYAAGVHR
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AP5Z1 adaptor related protein complex 5 zeta 1 subunit [ Homo sapiens (human) ]
• Official Symbol: AP5Z1
• Synonyms: AP5Z1; adaptor related protein complex 5 zeta 1 subunit; zeta; SPG48; KIAA0415; AP-5 complex subunit zeta-1; adapter-related protein complex 5 zeta subunit; adaptor-related protein complex 5 zeta subunit; zeta5
• Gene ID: 9907
• mRNA Refseq: NM_014855
• Protein Refseq: NP_055670
• MIM: 613653
• UniProt ID: O43299