Recombinant Human APOC3 protein, His/GST-tagged

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Recombinant Human APOC3 protein, His/GST-tagged

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Cat.No. : APOC3-393H
Product Overview : Recombinant Human APOC3(Ser21~Ala99) fused with His/GST tag at N-terminal was expressed in E. coli.
Description : Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in ap centigrade-III levels induces the development of hypertriglyceridemia.
Source : E. coli
Species : Human
Tag : His/GST
Form : Supplied as lyophilized form in 100mM NaHCO3, 500mM NaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
Molecular Mass : 40.7kDa
Protein length : Ser21~Ala99
AA Sequence : SEAEDASLLS FMQGYMKHAT KTAKDALSSV QESQVAQQAR GWVTDGFSSL KDYWSTVKDK FSEFWDLDPE VRPTSAVAA
Endotoxin : <1.0EU per 1µg (determined by the LAL method).
Purity : > 95%
Applications : SDS-PAGE; WB; ELISA; IP.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : APOC3 apolipoprotein C-III [ Homo sapiens ]
Official Symbol : APOC3
Synonyms : APOC3; apolipoprotein C-III; apo-CIII; ap centigrade-III; apolipoprotein C3; HALP2; APOCIII; MGC150353;
Gene ID : 345
mRNA Refseq : NM_000040
Protein Refseq : NP_000031
MIM : 107720
UniProt ID : P02656
Chromosome Location : 11q23-qter
Pathway : Chylomicron-mediated lipid transport, organism-specific biosystem; HDL-mediated lipid transport, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem; Lipoprotein metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; PPAR signaling pathway, organism-specific biosystem;
Function : cholesterol binding; enzyme regulator activity; high-density lipoprotein particle receptor binding; lipase inhibitor activity; phospholipid binding;

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