Recombinant Human ASGR1, GST-tagged

• Cat.No.: ASGR1-587H
• Product Overview: Recombinant Human ASGR1with gst-tag at N-terminal was produced in wheat germ expressionsystem in vitro, 57.75 kDa (291aa).

Specification

• Species: Human
• Source: Wheat Germ
• Tag: GST
• Description: This geneencodes a subunit of the asialoglycoprotein receptor. This receptor is atransmembrane protein that plays a critical role in serum glycoproteinhomeostasis by mediating the endocytosis and lysosomal degradation ofglycoproteins with exposed terminal galactose or N-acetylgalactosamineresidues. The asialoglycoprotein receptor may facilitate hepatic infection bymultiple viruses including hepatitis B, and is also a target forliver-specific drug delivery. The asialoglycoprotein receptor is ahetero-oligomeric protein composed of major and minor subunits, which areencoded by different genes. The protein encoded by this gene is the moreabundant major subunit. Alternatively spliced transcript variants encodingmultiple isoforms have been observed for this gene.
• Aminoacid sequence: MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL
• Purification: GlutathioneSepharose 4 Fast Flow
• Note: Best use withinthree months from the date of receipt of this protein.
• Applications: ELISA; WB; AntibodyProduction; Protein Array
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione,pH8.0 in the elution buffer.
• Storage: Store at -80°C. Aliquot to avoidrepeated freezing and thawing.
• OfficialSymbol: ASGR1

Gene Information

• Gene Name: ASGR1 asialoglycoprotein receptor1 [ Homo sapiens ]
• Synonyms: ASGR1;asialoglycoprotein receptor 1; HL-1; ASGPR; ASGPR1; CLEC4H1; hepatic lectinH1; C-type lectin domain family 4 member H1; OTTHUMP00000128354; ASGP-R 1
• Gene ID: 432
• mRNA Refseq: NM_001197216
• Protein Refseq: NP_001184145
• MIM: 108360
• UniProt ID: P07306
• Chromosome Location: 17p13.2
• Function: asialoglycoproteinreceptor activity; metal ion binding; protein binding