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Recombinant Human ATP2A1 Protein, MYC/DDK-tagged

Cat.No. : ATP2A1-2944H
Product Overview : Recombinant Human ATP2A1 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.
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  • Gene Information
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Description : This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 110.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [ Homo sapiens ]
Official Symbol : ATP2A1
Synonyms : ATP2A; SERCA1
Gene ID : 487
mRNA Refseq : NM_004320
Protein Refseq : NP_004311
MIM : 108730
UniProt ID : O14983

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are the expression and function of ATP2Arecombinant protein regulated in cardiomyocytes? 08/25/2022

Yes, the expression and function of ATP2A1 recombinant protein in cardiomyocytes are regulated by different regulatory mechanisms, such as endogenous hormones and signaling pathways.

What other proteins does the recombinant ATP2Aprotein interact with? 07/04/2022

The recombinant ATP2A1 protein interacts with other proteins of the sarcoplasmic reticulum, such as calsequestrin and phospholamban, to regulate muscle contraction.

Does the recombinant ATP2 Aprotein have drug target potential? 02/07/2021

The ATP2A1 recombinant protein can be used as a drug target because it plays an important role in regulating muscle and cardiomyocyte function. However, there are no clinically applicable drugs targeting ATP2A1.

What is the role of ATP2 Arecombinant protein in cardiovascular disease? 04/18/2020

Impairment of the normal function of ATP2A1 recombinant protein in cardiomyocytes may contribute to the development of cardiovascular diseases, such as reduced myocardial contractility and heart failure.

How does recombinant ATP2A protein play a role in muscle diseases? 02/28/2020

Mutations in the ATP2A1 recombinant protein may cause calcium leakage and abnormal muscle contraction, leading to muscle diseases.

How does the recombinant ATP2A protein interact with specific drugs? 10/27/2019

Certain drugs can affect the function of the recombinant ATP2A1 protein, such as calcium antagonists and cardiac agonists. These drugs regulate calcium homeostasis in muscle and cardiomyocytes.

Customer Reviews (3)

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Reviews
04/09/2022

    It is noteworthy that the results of multiple experiments were highly consistent and reproducible.

    12/19/2021

      The catalytic activity of ATP2A1 is very excellent, not only the catalytic effect is remarkable, but also has high selectivity, and its performance is impressive.

      06/28/2019

        They produced ATP2A1 with high purity and accurate experimental results.

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