| Description : |
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
110.1 kDa |
| AA Sequence : |
MEAAHAKTTEECLAYFGVSETTGLT PDQVKRNLEKYGLNELPAEEGKTLW ELVIEQFEDLLVRILLLAACISFVL AWFEEGEETITAFVEPFVILLILIA NAIVGVWQERNAENAIEALKEYEPE MGKVYRADRKSVQRIKARDIVPGDI VEVAVGDKVPADIRILAIKSTTLRV DQSILTGESVSVIKHTEPVPDPRAV NQDKKNMLFSGTNIAAGKALGIVAT TGVGTEIGKIRDQMAATEQDKTPLQ QKLDEFGEQLSKVISLICVAVWLIN IGHFNDPVHGGSWFRGAIYYFKIAV ALAVAAIPEGLPAVITTCLALGTRR MAKKNAIVRSLPSVETLGCTSVICS DKTGTLTTNQMSVCKMFIIDKVDGD ICLLNEFSITGSTYAPEGEVLKNDK PVRPGQYDGLVELATICALCNDSSL DFNEAKGVYEKVGEATETALTTLVE KMNVFNTDVRSLSKVERANACNSVI RQLMKKEFTLEFSRDRKSMSVYCSP AKSSRAAVGNKMFVKGAPEGVIDRC NYVRVGTTRVPLTGPVKEKIMAVIK EWGTGRDTLRCLALATRDTPPKREE MVLDDSARFLEYETDLTFVGVVGML DPPRKEVTGSIQLCRDAGIRVIMIT GDNKGTAIAICRRIGIFGENEEVAD RAYTGREFDDLPLAEQREACRRACC FARVEPSHKSKIVEYLQSYDEITAM TGDGVNDAPALKKAEIGIAMGSGTA VAKTASEMVLADDNFSTIVAAVEEG RAIYNNMKQFIRYLISSNVGEVVCI FLTAALGLPEALIPVQLLWVNLVTD GLPATALGFNPPDLDIMDRPPRSPK EPLISGWLFFRYMAIGGYVGAATVG AAAWWFLYAEDGPHVNYSQLTHFMQ CTEDNTHFEGIDCEVFEAPEPMTMA LSVLVTIEMCNALNSLSENQSLLRM PPWVNIWLLGSICLSMSLHFLILYV DPLPMIFKLRALDLTQWLMVLKISL PVIGLDEILKFVARNYLEDPEDERR KTRTRPLEQKLISEEDLAANDILDY KDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
