Recombinant Human ATP2A2 protein, GST-tagged
|Product Overview :||Human ATP2A2 full-length ORF ( NP_001672.1, 1 a.a. - 997 a.a.) recombinant protein with GST-tag at N-terminal.|
- Gene Information
- Related Products
|Description :||This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]|
|Source :||Wheat Germ|
|Molecular Mass :||136.1 kDa|
|AA Sequence :||MENAHTKTVEEVLGHFGVNESTGLS LEQVKKLKERWGSNELPAEEGKTLL ELVIEQFEDLLVRILLLAACISFVL AWFEEGEETITAFVEPFVILLILVA NAIVGVWQERNAENAIEALKEYEPE MGKVYRQDRKSVQRIKAKDIVPGDI VEIAVGDKVPADIRLTSIKSTTLRV DQSILTGESVSVIKHTDPVPDPRAV NQDKKNMLFSGTNIAAGKAMGVVVA TGVNTEIGKIRDEMVATEQERTPLQ QKLDEFGEQLSKVISLICIAVWIIN IGHFNDPVHGGSWIRGAIYYFKIAV ALAVAAIPEGLPAVITTCLALGTRR MAKKNAIVRSLPSVETLGCTSVICS DKTGTLTTNQMSVCRMFILDRVEGD TCSLNEFTITGSTYAPIGEVHKDDK PVNCHQYDGLVELATICALCNDSAL DYNEAKGVYEKVGEATETALTCLVE KMNVFDTELKGLSKIERANACNSVI KQLMKKEFTLEFSRDRKSMSVYCTP NKPSRTSMSKMFVKGAPEGVIDRCT HIRVGSTKVPMTSGVKQKIMSVIRE WGSGSDTLRCLALATHDNPLRREEM HLEDSANFIKYETNLTFVGCVGMLD PPRIEVASSVKLCRQAGIRVIMITG DNKGTAVAICRRIGIFGQDEDVTSK AFTGREFDELNPSAQRDACLNARCF ARVEPSHKSKIVEFLQSFDEITAMT GDGVNDAPALKKAEIGIAMGSGTAV AKTASEMVLADDNFSTIVAAVEEGR AIYNNMKQFIRYLISSNVGEVVCIF LTAALGFPEALIPVQLLWVNLVTDG LPATALGFNPPDLDIMNKPPRNPKE PLISGWLFFRYLAIGCYVGAATVGA AAWWFIAADGGPRVSFYQLSHFLQC KEDNPDFEGVDCAIFESPYPMTMAL SVLVTIEMCNALNSLSENQSLLRMP PWENIWLVGSICLSMSLHFLILYVE PLPLIFQITPLNVTQWLMVLKISLP VILMDETLKFVARNYLEPAILE|
|Applications :||Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array|
|Notes :||Best use within three months from the date of receipt of this protein.|
|Storage :||Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.|
|Storage Buffer :||50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.|
|Gene Name :||ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [ Homo sapiens (human) ]|
|Official Symbol :||ATP2A2|
|Synonyms :||ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2; DD; DAR; ATP2B; SERCA2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; SR Ca(2+)-ATPase 2
calcium pump 2; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; cardiac Ca2+ ATPase; endoplasmic reticulum class 1/2 Ca(2+) ATPase; EC 126.96.36.199
|Gene ID :||488|
|mRNA Refseq :||NM_001681|
|Protein Refseq :||NP_001672|
|UniProt ID :||P16615|
|◆ Recombinant Protein|
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|ATP2A2-14H||Recombinant Human ATP2A2-eGFP Protein (M1-S1042 end), N-10×His/Strep II-tagged||+Inquiry|
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|ATP2A2-463H||Recombinant Human ATP2A2 Protein, His/GST-tagged||+Inquiry|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
Mutations in the recombinant ATP2A2 protein are associated with several nervous system related diseases, such as neurodegenerative diseases and neurodysregulation.
ATP2A2 protein is a calcium pump protein containing multiple membrane channels and ATP-binding sites for the regulation of intracellular calcium homeostasis.
Yes, the expression and function of ATP2A2 recombinant protein in the nervous system are regulated by complex mechanisms, including endogenous signaling pathways and cell-to-cell interactions.
Yes, there are polymorphic variations or mutations in ATP2A2 recombinant protein, which may be related to the susceptibility and pathogenesis of nervous system related diseases.
The recombinant ATP2A2 protein is responsible for regulating calcium homeostasis and maintaining nerve cell communication in the nervous system.
The recombinant ATP2A2 protein interacts with other membrane proteins, such as calcium channels and transporters, to regulate the function of nerve cells.
Customer Reviews (3)Write a review
ATP2A2 is usually expressed endogenously to obtain recombinant ATP2A2 protein, and its expressed products are widely used in the fields of science and technology and biology, which are of great significance for the analysis of structure and function. -
The protein should be stored at low temperatures, commonly − 80 ° C or in liquid nitrogen to prevent protein inactivation and degradation. -
At present, the commonly used detection methods include Western blotting and ELISA, which can be used to detect the expression level and activity of ATP2A2 protein. -
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