Recombinant Human ATP2A2 protein, GST-tagged

Cat.No. : ATP2A2-970H
Product Overview : Human ATP2A2 full-length ORF ( NP_001672.1, 1 a.a. - 997 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 136.1 kDa
AA Sequence : MENAHTKTVEEVLGHFGVNESTGLS LEQVKKLKERWGSNELPAEEGKTLL ELVIEQFEDLLVRILLLAACISFVL AWFEEGEETITAFVEPFVILLILVA NAIVGVWQERNAENAIEALKEYEPE MGKVYRQDRKSVQRIKAKDIVPGDI VEIAVGDKVPADIRLTSIKSTTLRV DQSILTGESVSVIKHTDPVPDPRAV NQDKKNMLFSGTNIAAGKAMGVVVA TGVNTEIGKIRDEMVATEQERTPLQ QKLDEFGEQLSKVISLICIAVWIIN IGHFNDPVHGGSWIRGAIYYFKIAV ALAVAAIPEGLPAVITTCLALGTRR MAKKNAIVRSLPSVETLGCTSVICS DKTGTLTTNQMSVCRMFILDRVEGD TCSLNEFTITGSTYAPIGEVHKDDK PVNCHQYDGLVELATICALCNDSAL DYNEAKGVYEKVGEATETALTCLVE KMNVFDTELKGLSKIERANACNSVI KQLMKKEFTLEFSRDRKSMSVYCTP NKPSRTSMSKMFVKGAPEGVIDRCT HIRVGSTKVPMTSGVKQKIMSVIRE WGSGSDTLRCLALATHDNPLRREEM HLEDSANFIKYETNLTFVGCVGMLD PPRIEVASSVKLCRQAGIRVIMITG DNKGTAVAICRRIGIFGQDEDVTSK AFTGREFDELNPSAQRDACLNARCF ARVEPSHKSKIVEFLQSFDEITAMT GDGVNDAPALKKAEIGIAMGSGTAV AKTASEMVLADDNFSTIVAAVEEGR AIYNNMKQFIRYLISSNVGEVVCIF LTAALGFPEALIPVQLLWVNLVTDG LPATALGFNPPDLDIMNKPPRNPKE PLISGWLFFRYLAIGCYVGAATVGA AAWWFIAADGGPRVSFYQLSHFLQC KEDNPDFEGVDCAIFESPYPMTMAL SVLVTIEMCNALNSLSENQSLLRMP PWENIWLVGSICLSMSLHFLILYVE PLPLIFQITPLNVTQWLMVLKISLP VILMDETLKFVARNYLEPAILE
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [ Homo sapiens (human) ]
Official Symbol : ATP2A2
Synonyms : ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2; DD; DAR; ATP2B; SERCA2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; SR Ca(2+)-ATPase 2
calcium pump 2; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; cardiac Ca2+ ATPase; endoplasmic reticulum class 1/2 Ca(2+) ATPase; EC 3.6.3.8
Gene ID : 488
mRNA Refseq : NM_001681
Protein Refseq : NP_001672
MIM : 108740
UniProt ID : P16615

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (6)

Ask a question
Are ATP2A2 recombinant protein mutations associated with human nervous system related diseases? 01/17/2022

Mutations in the recombinant ATP2A2 protein are associated with several nervous system related diseases, such as neurodegenerative diseases and neurodysregulation.

What are the structural features of the recombinant ATP2A2 protein? 10/16/2021

ATP2A2 protein is a calcium pump protein containing multiple membrane channels and ATP-binding sites for the regulation of intracellular calcium homeostasis.

Is the expression and function of recombinant ATP2A2 protein regulated in the nervous system? 08/23/2021

Yes, the expression and function of ATP2A2 recombinant protein in the nervous system are regulated by complex mechanisms, including endogenous signaling pathways and cell-to-cell interactions.

Is there any polymorphic variation or mutation in ATP2A2 recombinant protein? 02/27/2021

Yes, there are polymorphic variations or mutations in ATP2A2 recombinant protein, which may be related to the susceptibility and pathogenesis of nervous system related diseases.

What is the function of ATP2A2 recombinant protein in the nervous system? 07/10/2020

The recombinant ATP2A2 protein is responsible for regulating calcium homeostasis and maintaining nerve cell communication in the nervous system.

Does the recombinant ATP2A2 protein interact with other proteins? 01/21/2020

The recombinant ATP2A2 protein interacts with other membrane proteins, such as calcium channels and transporters, to regulate the function of nerve cells.

Customer Reviews (3)

Write a review
Reviews
08/09/2020

    ATP2A2 is usually expressed endogenously to obtain recombinant ATP2A2 protein, and its expressed products are widely used in the fields of science and technology and biology, which are of great significance for the analysis of structure and function. -

    07/28/2019

      The protein should be stored at low temperatures, commonly − 80 ° C or in liquid nitrogen to prevent protein inactivation and degradation. -

      03/25/2019

        At present, the commonly used detection methods include Western blotting and ELISA, which can be used to detect the expression level and activity of ATP2A2 protein. -

        Ask a Question for All ATP2A2 Products

        Required fields are marked with *

        My Review for All ATP2A2 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        Stay Updated on the
        Latest Bioscience Trends

        Copyright © 2023 Creative BioMart. All Rights Reserved.

        Terms and Conditions        Privacy Policy