Recombinant Human ATP2A2 Protein, His/GST-tagged
|Product Overview :||Recombinant Human ATP2A2(Ile315~Met756) fused with His tag at N-terminal was expressed in E. coli.|
- Gene Information
- Related Products
|Description :||This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.|
|Source :||E. coli|
|Form :||100mMNaHCO3, 500mMNaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.|
|Molecular Mass :||78.2kDa|
|Protein length :||Ile315~Met756|
|Endotoxin :||<1.0EU per 1µg (determined by the LAL method)|
|Purity :||> 92%|
|Applications :||Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein.
|Stability :||The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.|
|Storage :||Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.|
|Reconstitution :||Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.|
|Gene Name :||ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [ Homo sapiens ]|
|Official Symbol :||ATP2A2|
|Synonyms :||DD; DAR; ATP2B; SERCA2|
|Gene ID :||488|
|mRNA Refseq :||NM_001681|
|Protein Refseq :||NP_001672|
|UniProt ID :||P16615|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
Mutations in the recombinant ATP2A2 protein are associated with several nervous system related diseases, such as neurodegenerative diseases and neurodysregulation.
ATP2A2 protein is a calcium pump protein containing multiple membrane channels and ATP-binding sites for the regulation of intracellular calcium homeostasis.
Yes, the expression and function of ATP2A2 recombinant protein in the nervous system are regulated by complex mechanisms, including endogenous signaling pathways and cell-to-cell interactions.
Yes, there are polymorphic variations or mutations in ATP2A2 recombinant protein, which may be related to the susceptibility and pathogenesis of nervous system related diseases.
The recombinant ATP2A2 protein is responsible for regulating calcium homeostasis and maintaining nerve cell communication in the nervous system.
The recombinant ATP2A2 protein interacts with other membrane proteins, such as calcium channels and transporters, to regulate the function of nerve cells.
Customer Reviews (3)Write a review
ATP2A2 is usually expressed endogenously to obtain recombinant ATP2A2 protein, and its expressed products are widely used in the fields of science and technology and biology, which are of great significance for the analysis of structure and function. -
The protein should be stored at low temperatures, commonly − 80 ° C or in liquid nitrogen to prevent protein inactivation and degradation. -
At present, the commonly used detection methods include Western blotting and ELISA, which can be used to detect the expression level and activity of ATP2A2 protein. -
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