Recombinant Human AUP1 protein, GST-tagged

• Cat.No.: AUP1-1036H
• Product Overview: Human AUP1 full-length ORF ( NP_853553.1, 1 a.a. - 410 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 72.2 kDa
• AA Sequence: MELPSGPGPERLFDSHRLPGDCFLL LVLLLYAPVGFCLLVLRLFLGIHVF LVSCALPDSVLRRFVVRTMCAVLGL VARQEDSGLRDHSVRVLISNHVTPF DHNIVNLLTTCSTPLLNSPPSFVCW SRGFMEMNGRGELVESLKRFCASTR LPPTPLLLFPEEEATNGREGLLRFS SWPFSIQDVVQPLTLQVQRPLVSVT VSDASWVSELLWSLFVPFTVYQVRW LRPVHRQLGEANEEFALRVQQLVAK ELGQTGTRLTPADKAEHMKRQRHPR LRPQSAQSSFPPSPGPSPDVQLATL AQRVKEVLPHVPLGVIQRDLAKTGC VDLTITNLLEGAVAFMPEDITKGTQ SLPTASASKFPSSGPVTPQPTALTF AKSSWARQESLQERKQALYEYARRR FTERRAQEAD
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AUP1 ancient ubiquitous protein 1 [ Homo sapiens ]
• Official Symbol: AUP1
• Synonyms: AUP1; ancient ubiquitous protein 1
• Gene ID: 550
• mRNA Refseq: NM_181575
• Protein Refseq: NP_853553
• MIM: 602434
• UniProt ID: Q9Y679