Recombinant Human B and T Lymphocyte Associated, His-tagged

• Cat.No.: BTLA-3037H
• Product Overview: Recombinant Human BTLA protein was expressed in E.coli with His-tag at the N-terminus. The molecular weight is 32689,8 Da.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 25-289 aa
• Description: B and T lymphocyte associated is a protein that in humans is encoded by the BTLA gene. BTLA has also been designated as CD272. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a ligand for tumour necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.
• Sequences of amino acids: 25-289 aa
• Formulation: Supplied in 20 mM Tris-HCl, 0.5 M NaCl, 1 mM 2-mercaptoethanol, pH:8.0 and contains not preservatives.

Gene Information

• Gene Name: BTLA B and T lymphocyte associated [ Homo sapiens ]
• Synonyms: BTLA1; CD272; FLJ16065; MGC129743; B- and T-lymphocyte attenuator; B and T lymphocyte attenuator; B- and T-lymphocyte-associated protein
• Gene ID: 151888
• mRNA Refseq: NM_181780
• Protein Refseq: NP_861445
• MIM: 607925
• UniProt ID: Q7Z6A9
• Chromosome Location: 3q13.2
• Pathway: Signaling in Immune system
• Function: protein binding; receptor activity