Recombinant Human BIRC5, His-tagged

• Cat.No.: BIRC5-31754TH
• Product Overview: Recombinant full length Human Survivin with an N terminal His tag ; predicted molecular weight: 18.6 kDa

Specification

• Description: This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
• Protein length: 142 amino acids
• Conjugation: HIS
• Molecular Weight: 18.600kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.
• Form: Lyophilised:Centrifuge the vial prior to opening. Reconstitute to aconcentration of 0.1-1.0 mg/ml in PBS.
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: None
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMGAPT LPPAWQPFLKDHRISTFKNWPFLEG CACTPERMAEAGFIHCPTENEPDLA QCFFCFKELEGWEPDDDPIEEHKKH SSGCAFLSVKKQFEELTLGEFLKLD RERAKNKIAKETNNKKKEFEETVKK VRRAIEQLAAMD
• Sequence Similarities: Belongs to the IAP family.Contains 1 BIR repeat.

Gene Information

• Gene Name: BIRC5 baculoviral IAP repeat containing 5 [ Homo sapiens ]
• Official Symbol: BIRC5
• Synonyms: BIRC5; baculoviral IAP repeat containing 5; API4, apoptosis inhibitor 4 , baculoviral IAP repeat containing 5; baculoviral IAP repeat-containing protein 5; EPR 1; survivin; survivin variant 3 alpha
• Gene ID: 332
• mRNA Refseq: NM_001012270
• Protein Refseq: NP_001012270
• MIM: 603352
• Uniprot ID: O15392
• Chromosome Location: 17q25.3
• Pathway: Apoptosis, organism-specific biosystem; Aurora A signaling, organism-specific biosystem; Aurora B signaling, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Colorectal cancer, organism-specific biosystem
• Function: Ran GTPase binding; chaperone binding; cobalt ion binding; cofactor binding; cysteine-type endopeptidase inhibitor activity