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Recombinant Human BPIFA1 Protein, His/GST-tagged

Cat.No. : BPIFA1-746H
Product Overview : Recombinant Human BPIFA1(Gln20~Val256) fused with His tag at N-terminal was expressed in E. coli.
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Description : This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known.
Source : E. coli
Species : Human
Tag : His/GST
Form : 100mMNaHCO3, 500mMNaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Molecular Mass : 54.6kDa
Protein length : Gln20~Val256
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 90%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : BPIFA1 BPI fold containing family A, member 1 [ Homo sapiens ]
Official Symbol : BPIFA1
Synonyms : BPIFA1; BPI fold containing family A, member 1; LUNX; NASG; PLUNC; SPURT; SPLUNC1; bA49G10.5; BPI fold-containing family A member 1; protein Plunc; von Ebner protein Hl; lung-specific protein X; ligand-binding protein RYA3; tracheal epithelium enriched protein; tracheal epithelium-enriched protein; nasopharyngeal carcinoma-related protein; palate, lung and nasal epithelium associated; secretory protein in upper respiratory tracts; palate lung and nasal epithelium clone protein; UNQ787/PRO1606
Gene ID : 51297
mRNA Refseq : NM_130852
Protein Refseq : NP_057667
MIM : 607412
UniProt ID : Q9NP55

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How is BPIFA1 protein linked to chronic obstructive pulmonary disease (COPD)? 01/27/2022

Studies have suggested that BPIFA1 protein expression is decreased in the airways of COPD patients, and it may play a role in the pathogenesis of the disease.

Is there a genetic component to BPIFA1 protein expression? 10/09/2017

Genetic variations in the BPIFA1 gene have been associated with altered BPIFA1 protein expression and may contribute to individual susceptibility to respiratory diseases.

Can BPIFA1 protein levels be influenced by environmental factors? 11/01/2016

Environmental factors such as air pollution and cigarette smoke have been shown to impact BPIFA1 protein expression in the airways, potentially contributing to respiratory disease pathogenesis.

Are there any diagnostic assays available for measuring BPIFA1 protein levels? 08/08/2016

Several research groups have developed assays for quantifying BPIFA1 protein levels in respiratory samples, but these assays are still under investigation for clinical use.

What animal models are used to study BPIFA1 protein function? 01/15/2016

Mouse models with BPIFA1 gene knockout or overexpression have been instrumental in elucidating the physiological roles of BPIFA1 protein in the respiratory tract.

Customer Reviews (3)

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02/11/2022

    researchers using thearnE protein can benefit from its high purity and quality, ensuring reliable results.

    03/02/2018

      This flexibility allows researchers to select the most suitable form for their particular experimental setup, enhancing the efficiency and accuracy of their trials.

      08/20/2017

        the BPIFA1 protein is available in different formats, including recombinant and purified variants.

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